GEO DataSets

(Submitter supplied) Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs and maturation into mature DCs. Mature DCs were differentiated in vitro from human monocytes under normoxic or hypoxic conditions and the gene expression profile was determined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3858

Platform:

GPL570

6 Samples

Download data: CEL, CHP

Analysis of mature dendritic cells (mDC) generated from monocytes under chronic hypoxia (1%O2). Hypoxia is a common feature at pathologic sites that creates a unique microenvironment affecting cell phenotype and behavior. Results provide insight into the impact of chronic hypoxia on mDC development.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL570

Series:

GSE22282

6 Samples

Download data: CEL, CHP

(Submitter supplied) Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs. Immature DCs were differentiated in vitro from human monocytes under normoxic (iDCs) or hypoxic (Hi-DCs) conditions and the gene expression profile was determined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2750

Platform:

GPL570

6 Samples

Download data: CEL

Analysis of immature dendritic cells (DCs) differentiated from monocytes under hypoxia for 4 days. DCs are antigen presenting cells whose development is influenced by the microenvironment. Hypoxia is an important constituent of the microenvironment of inflamed tissues.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL570

Series:

GSE6863

6 Samples

Download data: CEL

(Submitter supplied) Analysis of gene expressions in mouse splenic dendritic cells (DCs). DCs were purified into two subsets, CD8-positive and -negative ones. DCs were expanded in vivo by injecting Flt3L-producing tumors into the backs of C57BL/6 mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL, CHP

(Submitter supplied) This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differential expression of genes involved in actin bundling and immune response, but also for the stability of myelin and bone remodeling. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2763

Platform:

GPL96

8 Samples

Download data

Analysis of in vitro differentiated dendritic cells (DCs) from patients with PLOSL, an early onset dementia with bone cysts caused by mutations in DAP12 and TREM2 genes which encode important signaling molecules in DCs. Results provide further insight into mechanisms underlying PLOSL pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 3 genotype/variation sets

Platform:

GPL96

Series:

GSE3624

8 Samples

Download data

(Submitter supplied) Our group recently described a population of antigen presenting cells that appear to be critical in psoriasis pathogenesis, termed inflammatory myeloid dendritic cells (CD11c+ BDCA1-). Triggering receptor expressed on myeloid cells type-1 (TREM-1) signaling was a major canonical pathway in the published transcriptome of these cells. TREM-1 is a member of the immunoglobulin superfamily, active through the DAP12 signaling pathway, with an unknown ligand. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4597

Platform:

GPL571

15 Samples

Download data: CEL

Analysis of an in vitro model of peptidoglycan-activated monocytes as inflammatory myeloid dendritic cells (DCs). DCs are thought to have an important role in the pathogenesis of inflammatory skin lesions such as psoriasis. Results provide insight into molecular basis of psoriasis pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 agent sets

Platform:

GPL571

Series:

GSE42305

15 Samples

Download data: CEL

(Submitter supplied) TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, and can amplify cellular responses to Toll-like receptor (TLR) ligands such as bacterial lipopolysaccharide (LPS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3499

Platform:

GPL570

62 Samples

Download data: CEL

Analysis of cultured monocytes following TREM-1 activation by treatment with an antibody against TREM-1. TREM-1 is an immunoreceptor expressed on monocytes, macrophages, and neutrophils. Results provide insight into the cellular consequences of TREM-1 activation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 agent, 11 individual sets

Platform:

GPL570

Series:

GSE9988

62 Samples

Download data: CEL

(Submitter supplied) DAP12 is a transmembrane protein, expressed as a disulfide-bonded homodimer and bears an immunoreceptor tyrosine-based activation motif (ITAM). DAP12 is broadly expressed in hematopoietic cells and associates with a variety of cell surface receptors in lymphoid and myeloid cells. Macrophages express several DAP12-associated receptors including triggering receptors expressed by myeloid cells (TREM)-1,2 and 3, myeloid DAP12-associating lectin (MDL)-1, CD200R like proteins CD200R3/R4 and CD300C/D/E . more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of monocyte-derived Dendritic cells manufactured several times from one healthy donor and one single time from 8 different healthy donors to test the sources of variability Sources tested: Assay-related variability (8 samples), Manufacture-related variability (5 samples), Intra-donor-related variability (5 samples), inter-donor-related variability (9 samples)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

48 Samples

Download data: TXT