GEO DataSets

(Submitter supplied) LPS plus ISO and LPS plus PGE2 had non-additive effects on gene expression in RAW 264.7 cells Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

88 Samples

Download data

(Submitter supplied) LPS plus IFG and LPS plus 2MA had non-additive effects on gene expression in RAW 264.7 cells Keywords: time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

90 Samples

Download data

(Submitter supplied) All samples were gathered from mouse RAW 264.7 cells (macrophages). Control total RNA was extracted from untreated RAW 264.7 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. Test total RNA was extracted from lipopolysaccharide (100ng/ml) and lipopolysaccharide-binding protein (100pM) treated RAW 264.4 cells cultured for either 1, 2, 4, 8, 16 or 48 hours. This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL254

36 Samples

Download data

(Submitter supplied) Gene expression analysis of freshly isolated CD14+ human monocytes and monocytes cultured in the presence or absence of interferon (IFN) -gamma for 24 h and then stimulated with Pam3Cys, a Toll-like receptor (TLR) 2 ligand, for 6 h. Results provide insight into mechanisms by which IFN-gamma reprograms early macrophage differentiation and subsequent response to TLR ligands.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

10 Samples

Download data: CEL, CHP

(Submitter supplied) TREM-1 is an orphan immunoreceptor expressed on monocytes, macrophages, and neutrophils. TREM-1 associates with and signals via the adapter protein DAP12/TYROBP, which contains an immunoreceptor tyrosine-based activation motif (ITAM). TREM-1 activation by receptor cross-linking is pro-inflammatory, and can amplify cellular responses to Toll-like receptor (TLR) ligands such as bacterial lipopolysaccharide (LPS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3499

Platform:

GPL570

62 Samples

Download data: CEL

Analysis of cultured monocytes following TREM-1 activation by treatment with an antibody against TREM-1. TREM-1 is an immunoreceptor expressed on monocytes, macrophages, and neutrophils. Results provide insight into the cellular consequences of TREM-1 activation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 agent, 11 individual sets

Platform:

GPL570

Series:

GSE9988

62 Samples

Download data: CEL

(Submitter supplied) Alzheimer’s disease (AD) is the most common form of dementia and risk-influencing genetics implicates microglia and neuroimmunity in the pathogenesis of AD. iPSC-microglia are increasingly used as a model of AD but the relevance of common immune stimuli to model AD is unclear. We performed a detailed cross-comparison over time on the effects of combinatory stimulation of iPSC-microglia, and in particular their relevance to AD. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

10 Samples

Download data: TXT

(Submitter supplied) Hemozoin phagocytosis results in immunomodulation. This study was designed to explore gene expression responses to 15(S)-HETE in LPS-stimulated RAW 264.7 cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2995

6 Samples

Download data