Epigenetic regulation by Polycomb Repressive Complex 1 promotes Cerebral Cavernous Malformations - - GEO DataSets

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Epigenetic regulation by Polycomb Repressive Complex 1 promotes Cerebral Cavernous Malformations

(Submitter supplied) Cerebral cavernous malformations (CCMs) are anomalies that develop mainly in the cerebral vasculature. They result from mutations in CCM1/KRIT1, CCM2, or CCM3/PDCD10. Loss of CCM proteins triggers a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological pattern of gene expression within endothelial cells. The downstream target genes that are activated by KLF2 are mostly unknown. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25922
12 Samples

Download data: BW

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Accession:: GSE277234

ID:: 200277234

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