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Items: 1 to 20 of 42187

1.

Transcriptomic analysis of sheep hypothalamus on sex-dependent differences in body weight of progeny born to dams supplemented with omega-3 fatty acids or methionine during late-gestation

(Submitter supplied) Feeding dams during gestation affects the development of the offspring for their entire life. The objective of the current experiment was to evaluate the changes of the transcriptome in the hypothalamus of the offspring lambs born from dams supplemented with: i) a control diet (without lipids or methionine supplementation), ii) an omega 3 fatty acid supplementation, or iii) a methionine supplementation. more...
Organism:
Ovis aries
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30257
17 Samples
Download data: SF
Series
Accession:
GSE253249
ID:
200253249
2.

The Role and Mechanism of TEAD4 in Preimplantation Embryonic Development in Mice and Cattle

(Submitter supplied) Tead4 is a critical transcription factor expressed during preimplantation development and is essential for the expression of trophectoderm-specific genes in mice. However, the mechanism of Tead4’s function in mouse preimplantation development and its conservation across mammals remains unclear. Here, we report that Tead4 is a crucial transcription factor necessary for blastocyst formation in mice. Disruption of TEAD4 through base editing results in developmental arrest at the morula stage. more...
Organism:
Bos taurus; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL26012
16 Samples
Download data: TXT
Series
Accession:
GSE237418
ID:
200237418
3.

Combined analysis of temporal metabolomics and transcriptomics reveals the metabolic patterns in goat oocytes during maturation

(Submitter supplied) Well-balanced and orderly metabolism is a crucial prerequisite for promoting oogenesis. Involvement of single metabolites in oocyte development has been widely reported; however, the comprehensive metabolic framework controlling oocyte maturation is still lacking. In the present study, we employed an integrated temporal metabolomic and transcriptomic method to analyze metabolism in goat oocytes at key stages, revealing the global picture of the metabolic patterns during maturation. more...
Organism:
Capra hircus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27106
9 Samples
Download data: TXT
Series
Accession:
GSE246054
ID:
200246054
4.

Effect of early-life plane of nutrition on the transcriptional profile of the anterior pituitary gland in heifer calves

(Submitter supplied) The aim of this study was to examine changes in the transcriptional profile of the anterior pituitary gland of heifer calves offered varying planes of nutrition during the early life period. From approximately 3 weeks of age (19 ± 5 days of age) Angus X Holstein-Friesian heifer calves were offered either a high (HP, n=13) or moderate (MP, n=15) plane of nutrition to achieve target growth rates of 1.2 kg/d and 0.5 kg/d, respectively. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
28 Samples
Download data: TXT
Series
Accession:
GSE230543
ID:
200230543
5.

Soybean molasses increases subcutaneous fat deposition while reducing lipid oxidation in the meat of castrated lambs

(Submitter supplied) This study aimed to evaluate the effect of including soybean molasses (SM) on performance, blood parameters, carcass traits, meat quality, fatty acid and muscle (longissimus thoracis) transcriptomic profiles of castrated lambs. Twenty Dorper × Santa Inês lambs (20.06 ± 0.76 kg BW) were assigned to a randomized block design, stratified by BW, with the following treatments: CON - 0 g/kg of SM and SM20 - 200 g/kg of SM on DM basis, allocated in individual pens. more...
Organism:
Ovis aries
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19778
8 Samples
Download data: CSV, XLSX
Series
Accession:
GSE266406
ID:
200266406
6.

Pyruvate metabolism alters the epigenetic and transcriptional profile of bovine oocytes.

(Submitter supplied) Pyruvate, the end-product of glycolysis in aerobic conditions, is converted into acetyl-CoA inside the mitochondria of oocytes as a master fuel input for the tricarboxylic acid (TCA) cycle. The citrate generated in the TCA cycle can be directed to the cytoplasm and converted back to acetyl-CoA, being driven to lipid synthesis or, alternatively, being used as the substrate for histones acetylation. This work aimed to verify the impact of pyruvate metabolism on the dynamics of lysine 9 histone 3 acetylation (H3K9ac) and RNA transcription in bovine oocytes during in vitro maturation (IVM). more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23055
9 Samples
Download data: TXT
Series
Accession:
GSE246306
ID:
200246306
7.

Unraveling the elongating bovine conceptus microenvironment: Identification of gene transcripts and proteins along the conceptus-maternal interface in cattle

(Submitter supplied) The bovine conceptus elongates near Day 16 of development and releases interferon-tau (IFNT), disrupting the endometrial luteolytic mechanism to sustain luteal P4 and pregnancy. Conceptus factors other than IFNT modify local endometrial activities in support of pregnancy; however, the microenvironment is largely uncharacterized. We utilized a bovine conceptus-endometrial culture system to elucidate the microenvironment in the form of RNA and protein. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
45 Samples
Download data: XLSX
Series
Accession:
GSE256172
ID:
200256172
8.

Efficient small DNA fragment sequencing and miRNA, small RNA or csRNA-seq libraries using AVITI

(Submitter supplied) Next-Generation Sequencing (NGS) catalyzed breakthroughs across various scientific domains. Illumina's sequencing by synthesis method has long been essential for NGS but emerging technologies like Element Biosciences' sequencing by avidity (AVITI) represent a novel approach. It has been reported that AVITI offers improved signal-to-noise ratios and cost reductions. However, the method relies on rolling circle amplification which can be impacted by polymer size, raising questions about its efficacy sequencing small RNAs (sRNAs) libraries including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and others that are crucial regulators of gene expression and involved in various biological processes. more...
Organism:
Homo sapiens; Bison bison; Bos taurus
Type:
Other; Non-coding RNA profiling by high throughput sequencing
5 related Platforms
28 Samples
Download data: BEDGRAPH, GTF, TXT
Series
Accession:
GSE267848
ID:
200267848
9.

Alternative Polyadenylation and RNA Splicing Profile during Sheep Zygotic Genome Activation

(Submitter supplied) Zygotic genome activation (ZGA) is essential for early embryo development. Here, we reported that ZGA is initiated at 16-cell stage in sheep, as extensive alterations in gene expression and DNA methylation patterns, along with elevated levels of RNA polymerase II and developmental arrest was found at the 16-cell embryos. To uncover the sophisticated RNA metabolism during ZGA, we conducted weighted gene co-expression network analysis and identified 1957 critical maternal genes. more...
Organism:
Ovis aries
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23810
26 Samples
Download data: TXT
Series
Accession:
GSE270269
ID:
200270269
10.

Cell and tissue adaptation in the pulmonary autograft in a large animal model of the Ross procedure

(Submitter supplied) In the Ross procedure, a patient's pulmonary valve is transplanted into aortic position. Reoperation is needed in many cases due to failure through dilatation of the pulmonary autograft. To further understand the failure mechanisms, gene expression profiling of the autograft tissue was performed and compared to control aortic and pulmonary sinus tissue though bulk RNA-seq. Notable results include the upregulation of inflammatory pathways and genes coding for proteins important for the structural integrity of the tissue, such as extracellular matrix proteins, collagenases and elastases.
Organism:
Ovis aries
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27721
22 Samples
Download data: TXT
Series
Accession:
GSE269818
ID:
200269818
11.

Effect of overexpress of lncFABP4 on gene expression during adipogenic differentiation of buffalo intramuscular adipocytes

(Submitter supplied) To investigate the function lncFABP4 in the regulation of adipogenic differentiation, we overexpressed lncFABP4 in buffalo intramuscular adipocytes
Organism:
Bubalus bubalis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33338
6 Samples
Download data: FA, XLSX
Series
Accession:
GSE234915
ID:
200234915
12.

Compartmentalisation proteomics revealed endolysosomal protein network changes in goat model of atrial fibrillation

(Submitter supplied) To identify the role of the endolysosomal (EL) protein network in atrial fibrillation (AF), we applied a newly developed organelle isolation method to the AF goat model. To accomplish the goal, we used proteomics, transcriptomics, integrated analysis, enzyme assays, electron tomography, and western blotting and identified several regulating EL proteins, related protein networks and pathways.
Organism:
Capra hircus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27106
8 Samples
Download data: TXT
Series
Accession:
GSE228289
ID:
200228289
13.

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (bulk miRNA-seq)

(Submitter supplied) Mammary epithelial cells (MECs), the only cell type which could be capable of secreting milk in mammary gland, can be applied for the generation of transgenic mammary cell/gland bioreactor. However, continuously achieving large amount of high-quality goat MECs by non-invasion method, especially prepuberal MECs, in vitro has been a challenge. Here, we show that a small molecules cocktail enables the in vitro generation of chemically-induced mammary epithelial cells (CiMECs) with milk-secreting properties from goat ear fibroblasts. more...
Organism:
Capra hircus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL21299
6 Samples
Download data: TXT
Series
Accession:
GSE207893
ID:
200207893
14.

Single-cell Transcriptomes and Follicular Fluid Proteomics of Ovine Atretic Follicles Reveal the Underlying Mechanisms of Oocyte Degeneration

(Submitter supplied) Background: In mammals, female fertility is determined by the outcome of follicular development (ovulation or atresia). Follicular atresia is a complex physiological process that results in the degeneration of oocytes from the ovary. However, the molecular mechanisms of oocyte degeneration and key protein markers of follicular atresia remain unclear. In this study, we explored the complex transcriptional regulatory mechanisms and protein profiles in oocytes and follicular fluid in atretic follicle stages using single-cell RNA sequencing and tandem mass tag proteomics. more...
Organism:
Ovis aries
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27721
6 Samples
Download data: TXT
Series
Accession:
GSE268651
ID:
200268651
15.

Assessment of different enrichment methods revealed the optimal approach to identify bovine circRNAs

(Submitter supplied) To better study the bovine circRNA, we assessed the outcomes of circRNA identification using six enrichment approaches. RNA-sequencing analysis revealed that different approaches led to varied the ratio of uniquely mapped reads, false positive rate of identifying circRNAs, and the number of circRNAs per million clean reads. Besides, 507 of 4,051 identified bovine high confident circRNAs had shared splicing sites with human circRNAs.
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Third-party reanalysis
Platforms:
GPL23295 GPL26012
28 Samples
Download data: XLSX
Series
Accession:
GSE226717
ID:
200226717
16.

Embryo response to different progesterone concentrations during superovulation of Holstein heifers

(Submitter supplied) Greater progesterone (P4) concentrations during the follicular growth have been associated with greater quality of embryos produced by superovulated cows and heifers. However, it is yet to be determined the mechanisms by which oocyte exposure to greater P4 concentrations improves early embryo quality. The objective of this study was to evaluate the impact of different P4 concentrations during superovulation on the transcriptome profile of early bovine embryos. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
6 Samples
Download data: CSV
Series
Accession:
GSE249344
ID:
200249344
17.

Whole geneome methylation sequencing for bull fertility DNA mehylation biomarker

(Submitter supplied) High fertility and low fertility bulls were screened from the a 6000 bull database and then identify the sperm-derived DMR and DMC that assoiated with bull ferrtility via whole genome methtlation sequencing
Organism:
Bos taurus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL24230
12 Samples
Download data: CSV, XLSX
Series
Accession:
GSE211794
ID:
200211794
18.

RNA-seq analysis of age-specific growth characteristics in the rumen of Hanwoo (Korean native cattle) steers

(Submitter supplied) Hanwoo cattle are a Korean breed renowned for their cultural significance and high-quality beef, characterized by low cholesterol and high unsaturated fat ratio. Growth is divided into a growing phase focused on development and a fattening phase for marbling. Proper feed management, considering genetic and environmental factors, is vital for maximizing growth potential. The rumen plays a crucial role in digestion and gene expression regulation, with rumen fermentation being central to nutrient absorption and cattle health. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
61 Samples
Download data: TXT
Series
Accession:
GSE267733
ID:
200267733
19.

Single-cell Analysis of Adipose Tissues Revealed the Potential Cellular and Molecular Mechanism of Cold and Disease Resistance in Mongolian Cattle

(Submitter supplied) Adipose tissue plays essential roles in adapting to harsh environmental conditions in Mongolian cattle. To dig out the cellular and molecular mechanism of adipose tissue taking part in the tolerance of rough feeding, cold temperature and disease of Mongolian cattle, here, we applied single-nucleus RNA-seq to map the landscape of cell types and profiles of transcriptome of adipose tissues at different anatomical depots at single-nucleus resolution. more...
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26012
5 Samples
Download data: ZIP
Series
Accession:
GSE264101
ID:
200264101
20.

Epigenetic Basis for the Establishment of Ruminal Tissue-Specific Functions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Bos taurus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL26012
48 Samples
Download data: BEDGRAPH, BW, NARROWPEAK, TXT
Series
Accession:
GSE264346
ID:
200264346
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