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Items: 1 to 20 of 15306

1.

Developmental trajectory of unconventional T cells of the cynomolgus macaque thymus

(Submitter supplied) We profiled the differentiation pathways and heterogeneity of thymocytes in the young cynomolgus monkey thymus using single-cell RNA sequencing.
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23096
1 Sample
Download data: H5, MTX, TSV
Series
Accession:
GSE267379
ID:
200267379
2.

Cynomolgus macaques: Young vs Elder

(Submitter supplied) Transcriptional profiling of cynomolgus macaques liver tissue comparing control young macaques with elder macaques. Goal was to determine the liver genetic change with aging of macaques.
Organism:
Macaca fascicularis
Type:
Expression profiling by array
Platform:
GPL26395
13 Samples
Download data: CSV, TXT
Series
Accession:
GSE200368
ID:
200200368
3.

Preclinical study on safety and efficacy of GMP human umbilical cord mesenchymal stem cells in knee osteoarthritis

(Submitter supplied) Clinical trials of MSCs in the treatment of OA have been carried out and good results have been obtained. However, these data on the dose of transplanted cells, the number of transplants, the therapeutic effect especially cartilage regeneration and safety are incomplete. Therefore, we constructed a cynomolgus macaque model consistent with the pathogenesis of OA. We have also established clinical-grade human umbilical cord-derived mesenchymal stem cell line. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28212
30 Samples
Download data
Series
Accession:
GSE250569
ID:
200250569
4.

Atlas of Cynomolgus Macaque Hematopoiesis

(Submitter supplied) Self-renewal and differentiation are inherent properties of hematopoietic stem cells that are necessary to support hematopoiesis. However, the underlying mechanisms, especially in human, remain unclear. Here, using the cynomolgus macaque as a surrogate model, we develop a new gating strategy to isolate with high purity transplantable cynomolgus HSCs and generated a single-cell transcriptomic map of cynomolgus HSCs and progenitor cells, that covers the gestational period not analyzed in human. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28212
36 Samples
Download data: MTX, TSV
Series
Accession:
GSE262140
ID:
200262140
5.

Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination

(Submitter supplied) The non-human primate (NHP) model (specifically rhesus and cynomolgus macaques) has facilitated our understanding of the pathogenic mechanisms of yellow fever (YF) disease and allowed evaluation of safety and efficacy of YF-17D vaccines. However, the accuracy of this model in mimicking vaccine-induced immunity in humans remains to be fully determined. We used a system biology approach to compare hematological, biochemical, transcriptomic, innate and antibody-mediated immune responses in cynomolgus macaques and human participants following YF-17D vaccination. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22523
81 Samples
Download data: TXT
Series
Accession:
GSE253538
ID:
200253538
6.

Generation and characterization of inducible KRAB-dCas9 iPSCs from primates for cross-species CRISPRi

(Submitter supplied) Comparisons of molecular phenotypes across primates provide unique information to understand human biology and evolution and single-cell RNA-seq CRISPR interference screens are a powerful approach to analyze them. Here, we generate and validate three human, three gorilla and two cynomolgus iPS cell lines that carry a dox-inducible KRAB-dCas9 construct in the AAVS1 locus. We show that despite variable expression levels of KRAB-dCas9 among lines, comparable downregulation of target genes and comparable phenotypic effects are observed in a single-cell RNA-seq CRISPR interference screen. more...
Organism:
Homo sapiens; Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33700
2 Samples
Download data: CSV, H5
Series
Accession:
GSE241293
ID:
200241293
7.

Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes

(Submitter supplied) We found piRNAs with different lengths represented the predominant small RNA species in oocytes from the 12 explored species, except mouse. We found endo-siRNAs resulted from the truncated Dicer isoform were mouse-specific, and os-piRNAs associating with PIWIL3 in human oocytes are widespread in mammals and are typically with low levels of the 2’-3’-O-methylation. The sequences of many highly expressed piRNA clusters are fast-evolving compared with their syntenic genomic locations, and the TE families distributing in the conserved piRNA clusters are various between species.
Organism:
Macaca fascicularis; Oryctolagus cuniculus; Cricetulus griseus; Mesocricetus auratus; Mus musculus; Capra hircus; Rattus norvegicus; Danio rerio; Homo sapiens; Canis lupus familiaris; Sus scrofa domesticus; Cavia porcellus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other
12 related Platforms
138 Samples
Download data
Series
Accession:
GSE200470
ID:
200200470
8.

Cell-mediated Immune Response Signature to AAV Capsid in Cynomolgus Monkeys

(Submitter supplied) Cell-mediated immune (CMI) responses to adeno-associated virus (AAV) can lead to both tissue damage and loss of therapeutic transgene expression. Identifying robust biomarkers of CMI and understanding CMI mechanisms can be help to helpful in clinical practice and in advancement of AAV gene therapies. The present work evaluated PBMCs from non-human primates (NHP) before and 14 days following immunization with AAV9 capsid. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22523
102 Samples
Download data: TXT
Series
Accession:
GSE256418
ID:
200256418
9.

Generation and characterization of inducible KRAB-dCas9 iPSCs from primates for cross-species CRISPRi

(Submitter supplied) Comparisons of molecular phenotypes across primates provide unique information to understand human biology and evolution and single-cell RNA-seq CRISPR interference screens are a powerful approach to analyze them. Here, we generate and validate three human, three gorilla and two cynomolgus iPS cell lines that carry a dox-inducible KRAB-dCas9 construct in the AAVS1 locus. We show that despite variable expression levels of KRAB-dCas9 among lines, comparable downregulation of target genes and comparable phenotypic effects are observed in a single-cell RNA-seq CRISPR interference screen. more...
Organism:
Homo sapiens; Gorilla gorilla; Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL34203 GPL30882 GPL34204
68 Samples
Download data: RDS, XLSX
Series
Accession:
GSE255980
ID:
200255980
10.

A Biodistribution Study of OTV vs. ASO by Intravenous or Intrathecal Administration in Cynomolgus Monkeys

(Submitter supplied) The objective of this study is to evaluate ASO biodistribution and pharmacodynamic response following intravenous delivery of conjugated OTV, which utilizes transferrin-receptor binding to deliver ASO, vs. intrathecal delivery of naked ASO in cynomolgus monkeys, the current gold standard for ASO delivery. Three groups were included for comparison: 1) Negative control cohort = Four biweekly intravenous doses of saline (n=3); 2) IT cohort = Single intrathecal dose of 4mg MALAT1 ASO (n=3); 3)  OTV multi dose cohort = Four biweekly intravenous doses of 30mpk OTV:MALAT1 (n=3). more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28212
9 Samples
Download data: CSV, H5, MTX, TSV
Series
Accession:
GSE208114
ID:
200208114
11.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Homo sapiens; Macaca fascicularis
Type:
Protein profiling by protein array; Other
Platforms:
GPL30414 GPL27885 GPL33775
1258 Samples
Download data
Series
Accession:
GSE243663
ID:
200243663
12.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgG)

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...
Organism:
Macaca fascicularis; synthetic construct
Type:
Other
Platform:
GPL33775
261 Samples
Download data: XLSX
Series
Accession:
GSE243661
ID:
200243661
13.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgA)

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...
Organism:
synthetic construct; Macaca fascicularis
Type:
Other
Platform:
GPL33775
261 Samples
Download data: XLSX
Series
Accession:
GSE243660
ID:
200243660
14.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgG)

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...
Organism:
synthetic construct; Macaca fascicularis
Type:
Protein profiling by protein array
Platform:
GPL30414
270 Samples
Download data: XLSX
Series
Accession:
GSE243659
ID:
200243659
15.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...
Organism:
Macaca fascicularis; synthetic construct
Type:
Protein profiling by protein array
Platform:
GPL30414
270 Samples
Download data: XLSX
Series
Accession:
GSE243658
ID:
200243658
16.

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM30 IgM)

(Submitter supplied) Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. more...
Organism:
Macaca fascicularis; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL27885
196 Samples
Download data: XLSX
Series
Accession:
GSE243657
ID:
200243657
17.

Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome

(Submitter supplied) It is well established that obese animals and humans show deficiencies in skeletal muscle content and metabolism. However, the mechanisms under how skeletal muscle metabolism affects systemic energy homeostasis is not well-defined. Here, we compared the skeletal muscle transcriptome from obese and lean controls in different species. We found an immune-responsive transcription factor interferon regulatory factor 4 (IRF4) was conserved to be increased in obese subjects from the three species (humans, non-human primates and mice). more...
Organism:
Macaca fascicularis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28492
2 Samples
Download data: TXT
Series
Accession:
GSE180906
ID:
200180906
18.

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-g and NK cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Macaca fascicularis
Type:
Expression profiling by array
Platform:
GPL29936
65 Samples
Download data: RCC
Series
Accession:
GSE243734
ID:
200243734
19.

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-g and NK cells [BALF_BloodNK_SARSWu_NHP]

(Submitter supplied) SARS-CoV-2 RNA generally becomes undetectable in upper airways after a few days or weeks post-infection. It is unclear however if the virus persists in other parts of the body and which mechanism(s) regulate SARS-CoV-2 persistence. We addressed this question in the macaque model. Replication-competent virus was detected in bronchioalveolar lavages (BAL) macrophages beyond 6 months post-infection. SARS-CoV-2 propagated in BAL macrophages from cell-to-cell. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by array
Platform:
GPL29936
24 Samples
Download data: RCC, TXT
Series
Accession:
GSE243733
ID:
200243733
20.

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-g and NK cells [BALF_NK_SARSWu_NHP]

(Submitter supplied) SARS-CoV-2 RNA generally becomes undetectable in upper airways after a few days or weeks post-infection. It is unclear however if the virus persists in other parts of the body and which mechanism(s) regulate SARS-CoV-2 persistence. We addressed this question in the macaque model. Replication-competent virus was detected in bronchioalveolar lavages (BAL) macrophages beyond 6 months post-infection. SARS-CoV-2 propagated in BAL macrophages from cell-to-cell. more...
Organism:
Macaca fascicularis
Type:
Expression profiling by array
Platform:
GPL29936
20 Samples
Download data: RCC, TXT
Series
Accession:
GSE243732
ID:
200243732
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