txid9541[Organism:noexp] - GEO DataSets

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Select item 2001977451.

Single cell transcriptomic profiling of corneal epithelium of diabetic non-human primates reveals that FOXO3 regulates ROS by reprogramming glucose metabolism

(Submitter supplied) Hyperglycemia leads to functional decline of various corneal cells, which induces corneal diseases. However, cellular and molecular mechanisms underlying how hyperglycemia affects the corneal epithelium have not been determined. Here, by undertaking single-cell transcriptomics of corneal epithelial cells obtained from healthy and diabetic non-human primates, we identified cell type-specific transcriptional alterations and shared changes across cell types, such as upregulation of FOXO3. more...

Organism:: Macaca fascicularis; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL23096 GPL20795
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE197745

ID:: 200197745

PubMed

Select item 2002460922.

Transcriptional Responses to TREM2 Agonist Antibody Treatment in Cynomologus Monkey Brain - Study 2

(Submitter supplied) Monkeys were treated with a single i.v 200 mg/kg dose of hPara.09 or Anti-gD (Isotype control). Brain was harvested on days 4 and 28, and RNA was extracted from the cerebral cortex. The following groups are included: Group 1: Day 4 gD 200mg/kg n=6; Group 2: Day 4 hPara.09 200 mg/kg n=6; Group 3: Day 28 gD 200mg/kg n= 6; Group 4: Day 28 hPara.09 200 mg/kg n=6 (24 animals total). To assess expression heterogeneity between brain samples, 2 different frontal cortex punches were taken from each monkey, resulting in 48 total samples.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20302
48 Samples

Download data: TAB

Series

Accession:: GSE246092

ID:: 200246092

PubMed

Select item 2002412173.

Transcriptional Responses to TREM2 Agonist Antibody Treatment in Cynomologus Monkey Brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20302 GPL24953
52 Samples

Download data: H5, TAB

Series

Accession:: GSE241217

ID:: 200241217

PubMed

Select item 2002411904.

Transcriptional Responses to TREM2 Agonist Antibody Treatment in Cynomologus Monkey Brain [single nuclei RNA sequencing]

(Submitter supplied) In order to search for pharmacodynamic biomarkers of a TREM2 agonist antibody (Para09) in primates we performed single nuclei RNA-Seq on cortical tissue from cynomolgus monkeys after single IV injected doses. Changes in proliferation genes such as MKI67 were observed, as well as genes associated with glial activation, such as CHI3L1. This experiment demonstrates that our antibody induces transcriptional changes in the brain after peripheral administration.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24953
16 Samples

Download data: H5

Series

Accession:: GSE241190

ID:: 200241190

PubMed

Select item 2002364535.

Transcriptional Responses to TREM2 Agonist Antibody Treatment in Cynomologus Monkey Brain [bulk RNA-seq]

(Submitter supplied) In order to search for pharmacodynamic biomarkers of a TREM2 agonist antibody (Para09) in primates we performed bulk RNA-Seq on cortical tissue from cynomolgus monkeys after single IV injected doses. Changes in proliferation genes such as MKI67 were observed, as well as genes associated with glial activation, such as CHI3L1. This experiment demonstrates that our antibody induces transcriptional changes in the brain after peripheral administration.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20302
36 Samples

Download data: TAB

Series

Accession:: GSE236453

ID:: 200236453

PubMed

Select item 2001499566.

RNA sequencing of lung tissue of cynomolgus monkeys

(Submitter supplied) RNA sequencing of lung tissue of young/old male/female cynomolgus monkeys

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23096
16 Samples

Download data: TXT

Series

Accession:: GSE149956

ID:: 200149956

SRA Run Selector

Select item 2002461487.

Preclinical efficacy of a live vesicular stomatitis virus-based Lassa virus vaccine candidate advanced for human clinical trials

(Submitter supplied) We advanced a promising experimental vaccine for immunizing against the Lassa virus surface glycoprotein as a candidate for human trials. Preclinical evaluation of the vaccine candidate based on a live vesicular stomatitis virus (VSV) vector showed that it was highly efficacious in cynomolgus macaques consistent with earlier research studies, and that the animals developed serum antibodies that could mediate antiviral effector functions including direct neutralization of virus infectivity. more...

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24953
39 Samples

Download data: TXT

Series

Accession:: GSE246148

ID:: 200246148

Select item 2002804418.

Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

(Submitter supplied) The foundation of many human-specific traits is likely established during early embryonic development. To understand these molecular processes, we compared gene expression dynamics in embryoid bodies (EBs) differentiated from iPSCs of four primate species: human, orangutan, cynomolgus, and rhesus macaque. We performed scRNA-seq on ∼ 85,000 cells after 8 and 16 days of EB differentiation, identifying diverse cell types across all three germ layers. more...

Organism:: Macaca mulatta; Pongo abelii; Macaca fascicularis; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL35048 GPL35049 GPL35050
10 Samples

Download data: H5

Series

Accession:: GSE280441

ID:: 200280441

Select item 2002812909.

A Penta-Component Mpox mRNA Vaccine Induced Protective Immunity in Naive and Simian Immunodeficiency Virus Infected Nonhuman Primates

(Submitter supplied) The transcriptome profiles of tissues from sham or AR- MPXV immunized macaques after MPXV infection.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20302
14 Samples

Download data: XLS

Series

Accession:: GSE281290

ID:: 200281290

Select item 20028071810.

Cross-species Single-cell Transcriptomics Reveals Neuronal Similarities and Heterogeneity in Amniote Pallium

(Submitter supplied) The amniote pallium, a vital component of the forebrain, has undergone considerable evolutionary divergence across species and is critical for a variety of functions including sensation, memory and learning. The relationship between pallial subregions in different species remain elusive, particularly regarding the identification of homologous neurons and their similar or distinct signatures. Here, we utilized single-nucleus RNA sequencing to examine over 130,000 nuclei from macaque (Macaca fascicularis) neocortex, alongside datasets from human (Homo sapiens), mouse (Mus musculus), zebra finch(Taeniopygia guttata), turtle (Chrysemys picta bellii), and lizard (Pogona vitticeps), for a cross-species comparison.

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34438
85 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE280718

ID:: 200280718

Select item 20027675311.

An accelerated Parkinson’s disease monkey model using AAV-α-synuclein plus Poly(ADP-ribose)

(Submitter supplied) The etiology of Parkinson’s disease (PD) remains elusive, and the limited availability of suitable animal models hampers research on pathogenesis and drug development. We report the development of a cynomolgus monkey model of PD that combines AAV-mediated overexpression of α-synuclein into the substantia nigra with injection of Poly(ADP-ribose) (PAR) into the striatum. Our results show that pathological processes were accelerated, including dopaminergic neuron degeneration, Lewy Bodies aggregation, and hallmarks of inflammation in microglia and astrocytes. more...

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28212
32 Samples

Download data: MTX, TSV

Series

Accession:: GSE276753

ID:: 200276753

Select item 20027618412.

Single-cell transcriptomic analysis reveals dynamic cellular processes in corneal epithelium during wound healing in cynomolgus monkeys

(Submitter supplied) we employed single-cell RNA sequencing (scRNA-seq) to analyze the cellular activities and transcriptional changes of corneal limbal epithelial cells at different stages after wound healing in cynomolgus monkeys

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27448
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE276184

ID:: 200276184

PubMed

Select item 20024166513.

Wnt signaling activation confers a syncytiotrophoblast progenitor state on trophoblast stem cells of cynomolgus monkey.

(Submitter supplied) Trophoblast stem cells (TSCs), derived from the trophectoderm of the blastocyst, are used as an in vitro model to reveal the underlying mechanisms of placentation in the mammal. In humans, suitable culture conditions for TSC derivation have been recently discovered. The established human TSCs differentiate efficiently toward two trophoblast subtypes, i.e., syncytiotrophoblast (STB) and extravillous trophoblast. more...

Organism:: Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28212
8 Samples

Download data: XLSX

Series

Accession:: GSE241665

ID:: 200241665

PubMed

Select item 20027605814.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development [scRNAseq and scATACseq]

(Submitter supplied) Embryos from different mammalian species develop at characteristic timescales. These timescales are recapitulated during the differentiation of pluripotent stem cells in vitro. Specific genes and molecular pathways that modulate cell differentiation speed between mammalian species remain to be identified. Here we use single-cell multi-omic analysis of neural differentiation of mouse, cynomolgus monkey and human pluripotent cells to identify new regulators for differentiation speed. more...

Organism:: Homo sapiens; Mus musculus; Macaca fascicularis

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL28212 GPL24247 GPL24676
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE276058

ID:: 200276058

Select item 20027557215.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens; Macaca fascicularis

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

7 related Platforms
23 Samples

Download data: MTX, TSV

Series

Accession:: GSE275572

ID:: 200275572

Select item 20027557116.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development [mTORi]

Organism:: Macaca fascicularis; Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL34284 GPL34842 GPL34290
15 Samples

Download data: MTX, TSV

Series

Accession:: GSE275571

ID:: 200275571

Select item 20027556617.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development [UGP2 KO]

Organism:: Homo sapiens; Macaca fascicularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL34841
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE275566

ID:: 200275566

Select item 20024377018.

Estrogen-triggered Monkey Multi-Organ Cell Atlas [scRNA-Seq]

(Submitter supplied) Awareness of estrogen's effects on health is broadening rapidly. The effects of long-term high levels of estrogen on the body involve multiple organs. Here we use both single cell chromatin accessibility and RNA sequencing data to analyze the potential effect of estrogen on major organ at single cell levels.