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Items: 1 to 20 of 114

1.

Genome-wide maps of gene transcription level in wild-type and mpbR-deleted Mycobacterium tuberculosis H37Ra strains

(Submitter supplied) We report the application of RNA-seq technology for high-throughput profiling of gene transcription in M. tuberculosis H37Ra strains. By obtaining over four billion bases of sequence from mRNA, we generated genome-wide gene transcription maps of wild-type and mpbR-deleted Mycobacterium tuberculosis H37Ra strains. We find that a group of genes is significantly up-regulated in the mpbR-deleted mutant strain. more...
Organism:
Mycobacterium tuberculosis H37Ra
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27144
6 Samples
Download data: TXT
Series
Accession:
GSE136322
ID:
200136322
2.

Transcription profile of intracellular H37Ra of bEnd.3 and Raw 264.7 cells

(Submitter supplied) Transcription profile of intracellular H37Ra of bEnd.3 and Raw 264.7 cells 3 d.p.i
Organism:
Mycobacterium tuberculosis H37Ra
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29448
4 Samples
Download data: TXT
Series
Accession:
GSE162200
ID:
200162200
3.

Next Generation Sequencing Facilitates Quantitative Analysis of cmtR-deleted mutant and wild-type strains Transcriptomes in Mycobacterium tuberculosis H37Ra

(Submitter supplied) Compare the gene expression difference between MRA_2010 knockout strains and wild-type strains by RNA sequencing in Mycobacterium tuberculosis H37Ra. The goal of this study is that detection cmtR acts as a transcriptional factor and regulates the target genes expression.
Organism:
Mycobacterium tuberculosis H37Ra
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27144
6 Samples
Download data: XLSX
Series
Accession:
GSE140113
ID:
200140113
4.

Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing and RNA interference in Mycobacterium tuberculosis

(Submitter supplied) Purpose: Understanding the functional genomics of M.tb (Mycobacterium tuberculosis) and development of novel anti-M.tb drugs and vaccines needs an efficient gene edit tool. The aim of this study was to describe an easy and efficient gene edit tool for functional genomics study of M.tb. Method: A plasmid was designed containing mini CRISPR array and 400bp up and downside homologues DNA sequences from the target gene interposed by EGFP or BFP. more...
Organism:
Mycobacterium tuberculosis H37Ra
Type:
Other
Platform:
GPL23674
3 Samples
Download data: VCF
Series
Accession:
GSE103276
ID:
200103276
5.

Adaptive Gene Profiling of Mycobacterium Tuberculosis during Sub-lethal Kanamycin Exposure

(Submitter supplied) Objectives: Mtb adaptation is the major threat to affective disease control.The objective of this study was to identify major contributors participating in Mtb adaptation process during sub-lethal drug exposure through next generation sequencing Methods: The sequence reads that passed quality filters were analyzed through Tophat-2 and HT-Seq after being unified with housekeeping genes expression level.Adaptation analysis was performed through classifying genes expression in count table by K-Means clustering algorithm and find interested genes pattern Results: Genes responsible for lipid metabolism strongly repressed while involved in virulence and information pathways up regulated under sub-lethal kanamycin stress.Moreover an adaptive network comprise of Ra1750,Ra3160,Ra3161,Ra2492 and Ra3893 identified in kanamycin treated Mtb Conclusions: Mtb has a complex regulatory inter-connected gene network supporting its survival under diverse environmental conditions.
Organism:
Mycobacterium tuberculosis H37Ra
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23674
7 Samples
Download data: TSV
Series
Accession:
GSE100915
ID:
200100915
6.

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

(Submitter supplied) Genome-wide distribution of topoisomerase I and DNA gyrase is directed by transcription induced supercoiling
Organism:
Mycobacterium tuberculosis H37Ra; Mycobacterium tuberculosis H37Rv
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17967 GPL23183
5 Samples
Download data: BED, TXT
Series
Accession:
GSE85357
ID:
200085357
7.

MtrA is involved in progression of Mycobacterium tuberculosis cell cycle

(Submitter supplied) Synchronised cultures of Mycobacterium tuberculosis (M. tb H37Ra DnaAcos115) were used to determine the cell cycle dependent gene expression.
Organism:
Mycobacterium tuberculosis; Mycobacterium tuberculosis H37Ra
Type:
Expression profiling by array
Platform:
GPL4057
18 Samples
Download data: GPR
Series
Accession:
GSE53640
ID:
200053640
8.

Discovery of the genes controlled by the second messenger cyclic di-GMP in Mycobacterium tuberculosis

(Submitter supplied) Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many biological processes in bacteria. The genome in Mycobacterium tuberculosis encodes a single copy of the diguanylate cyclase gene (dgc) responsible for c-di-GMP synthesis. To determine the role of c-di-GMP signaling in M. tuberculosis, the mutant strain of Δdgc was generated in the virulent H37Rv strain. We used whole genome microarray expression profiling as a discovery platform to identify the genes controlled by c-di-GMP in M. more...
Organism:
Mycobacterium tuberculosis H37Ra; Mycobacterium tuberculosis
Type:
Expression profiling by array
Platform:
GPL15565
5 Samples
Download data: TXT
Series
Accession:
GSE37973
ID:
200037973
9.

A PhoP point mutation discriminates between the virulent H37Rv and avirulent H37Ra strains of Mycobacterium tuberculosis

(Submitter supplied) To uncover mutations underlying the attentuation of H37Ra, we embarked on sequencing its genome using a novel massive parallel pyrosequencing technology. Comparison with the virulent H37Rv parental strain revealed only few polymorphisms, one of which was located in the DNA binding domain of the transcriptional regulator PhoP. Keywords: Expresion profiling
Organism:
Mycobacterium tuberculosis H37Ra; Mycobacterium tuberculosis; Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by array
Platform:
GPL5095
50 Samples
Download data: TXT
Series
Accession:
GSE7539
ID:
200007539
10.

Illumina NovaSeq 6000 (Mycobacterium tuberculosis H37Ra)

Organism:
Mycobacterium tuberculosis H37Ra
Download data
Platform
Accession:
GPL34978
ID:
100034978
11.

HiSeq X Ten (Mycobacterium tuberculosis H37Ra)

Organism:
Mycobacterium tuberculosis H37Ra
1 Series
4 Samples
Download data
Platform
Accession:
GPL29448
ID:
100029448
12.

Illumina HiSeq 2500 (Mycobacterium tuberculosis H37Ra)

Organism:
Mycobacterium tuberculosis H37Ra
2 Series
12 Samples
Download data
Platform
Accession:
GPL27144
ID:
100027144
13.

Agilent-045823 Mycobacterium tuberculosis [Feature Number]

(Submitter supplied) see manufacturer's website
Organism:
Mycobacterium tuberculosis H37Ra
Download data: XLSX
Platform
Accession:
GPL23959
ID:
100023959
14.

Illumina HiSeq 2000 (Mycobacterium tuberculosis H37Ra)

Organism:
Mycobacterium tuberculosis H37Ra
2 Series
10 Samples
Download data
Platform
Accession:
GPL23674
ID:
100023674
15.

Illumina Genome Analyzer IIx (Mycobacterium tuberculosis H37Ra)

Organism:
Mycobacterium tuberculosis H37Ra
1 Series
3 Samples
Download data
Platform
Accession:
GPL23183
ID:
100023183
16.

022125-Agilent Mycobacterium tuberculosis H37Ra 8x15K (Probe Name version)

(Submitter supplied) See manufacturer's web site at http://www.agilent.com/
Organism:
Mycobacterium tuberculosis H37Ra
1 Series
5 Samples
Download data
Platform
Accession:
GPL15565
ID:
100015565
17.

022125-Agilent Mycobacterium tuberculosis H37Ra 8x15K (Feature Number version)

(Submitter supplied) See manufacturer's web site at http://www.agilent.com/
Organism:
Mycobacterium tuberculosis H37Ra
Download data
Platform
Accession:
GPL15551
ID:
100015551
18.

KO3

Organism:
Mycobacterium tuberculosis H37Ra
Source name:
strain
Platform:
GPL27144
Series:
GSE136322
Download data
Sample
Accession:
GSM4044996
ID:
304044996
19.

KO2

Organism:
Mycobacterium tuberculosis H37Ra
Source name:
strain
Platform:
GPL27144
Series:
GSE136322
Download data
Sample
Accession:
GSM4044995
ID:
304044995
20.

KO1

Organism:
Mycobacterium tuberculosis H37Ra
Source name:
strain
Platform:
GPL27144
Series:
GSE136322
Download data
Sample
Accession:
GSM4044994
ID:
304044994
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