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Items: 1 to 20 of 770

1.

Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol

(Submitter supplied) Background: Alcohol misuse, binge drinking pattern, and gender-specific effects in the middle-aged population has been clearly underestimated. In the present study, we focused on understanding gender-specific effects of alcohol exposure on the gut-liver axis and the role of gut microbiota in modulating gender-specific responses to alcohol consumption. Methods: Fifty-two-week-old female and male C57BL/6 mice were fasted for 12 h, and then administered a single oral dose of ethanol (EtOH) (6 g/kg). more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL34367
11 Samples
Download data: CSV
Series
Accession:
GSE263477
ID:
200263477
2.

Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8

(Submitter supplied) DOCK8 is required for T cell-dependent gut IgA by maintaining plasma cell metabolic fitness
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
60 Samples
Download data: TXT
Series
Accession:
GSE198847
ID:
200198847
3.

Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis

(Submitter supplied) Microbiome dysregulation affects the estrogen metabolism (estrobolome) profile which in turns affects the immunological response. Estrogen hormone is an essential hormone that regulates the sexual activity in females as well as immune response in both sexes. Endometriosis is one of complicated disorder influnce the fertility of females due to escape of endometrial tissue into peritoneal cavity where the immunotoxicity will be undertaken. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
16 Samples
Download data: TXT
Series
Accession:
GSE248213
ID:
200248213
4.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress super

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; mouse gut metagenome; Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL21626 GPL21051 GPL17769
26 Samples
Download data: TSV, XLSX
Series
Accession:
GSE220884
ID:
200220884
5.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress [16S]

(Submitter supplied) To determine how constitutively active autophagy in Becn1F121A mice affects the fecal microbiota, we performed a 16s analysis.
Organism:
synthetic construct; mouse gut metagenome
Type:
Other
Platforms:
GPL17769 GPL21051
2 Samples
Download data: TSV, XLSX
Series
Accession:
GSE220883
ID:
200220883
6.

Spatial transcriptomics revealing host-microbe interactions

(Submitter supplied) We developed an analysis pipeline that can extract microbial sequences from Spatial Transcriptomic (ST) data and assign taxonomic labels, generating a spatial microbial abundance matrix in addition to the default host expression matrix, enabling simultaneous analysis of host expression and microbial distribution. We called the pipeline Spatial Meta-transcriptome (SMT) and applied it on both human and murine intestinal sections and validated the spatial microbial abundance information with alternative assays. more...
Organism:
mouse gut metagenome; Mus musculus
Type:
Other
Platforms:
GPL32553 GPL32554
10 Samples
Download data: PNG, RDS, TAR, TSV
Series
Accession:
GSE210738
ID:
200210738
7.

Regulation of Intestinal microbiome diversity by BTLA and HVEM

(Submitter supplied) The intestinal microbiome was examined from fecal pellets of animals with genetic targeting of the BTLA inhibitory receptor and the TNFR superfamily member HVEM, or in animals treated with agonist antibodies specific for BTLA.
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
45 Samples
Download data: XLSX
Series
Accession:
GSE195890
ID:
200195890
8.

Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

(Submitter supplied) Microbial dysbiosis is a colorectal cancer (CRC) hallmark and contributes to inflammation, tumor growth, and therapy response. Gut microbes signal via metabolites, but how the metabolites impact CRC is largely unknown. We interrogated fecal metabolites associated with mouse models of colon tumorigenesis with varying mutational load. We found that microbial metabolites from healthy mice or humans were growth-repressive, and this response was attenuated in mice and patients with CRC. more...
Organism:
synthetic construct; mouse gut metagenome; Bacteria; feces metagenome
Type:
Other
4 related Platforms
71 Samples
Download data: TXT
Series
Accession:
GSE186880
ID:
200186880
9.

Effect of certain microorganisms on mouse gut microbial communities.

(Submitter supplied) Effect of certain microorganisms on mouse gut microbial communities in aged group.
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
30 Samples
Download data: TXT
Series
Accession:
GSE180087
ID:
200180087
10.

Gut microbiome dysregulation is associated with elevated toxic bile acids in Parkinson’s disease

(Submitter supplied) The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD) patients. The vermiform appendix is a lymphoid tissue implicated in the storage and regulation of the gut microbiome. Here, we investigate changes in the functional microbiome in the appendix of PD patients relative to controls by metatranscriptomic analysis. In the PD appendix, we find microbial dysbiosis affecting lipid metabolism, particularly an upregulation of bacteria responsible for secondary bile acid synthesis. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
40 Samples
Download data: CSV, TSV
Series
Accession:
GSE156647
ID:
200156647
11.

16s rDNA-sequencing of gut microbiota in Temozolomide-treated glioma mice

(Submitter supplied) Purpose: Gut microbiota is associated with the progression of brain tumor. However, the alterations in the gut microbiota during glioma growth and temozolomide (TMZ) therapy remains to be understood. Methods: C57BL/6 male mice were implanted with GL261 glioma cells. TMZ/sodium carboxymethyl cellulose (SCC) was administered by gavage for five consecutive days (from 8 to 12 days after implantation). Fecal samples were collected before (T0) and on days 7 (T1), 14 (T2), and 28 (T3) after implantation. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL22735
48 Samples
Download data: TXT, XLS
Series
Accession:
GSE171041
ID:
200171041
12.

Microbiota alteration upon blueberry consumption

(Submitter supplied) We demonstrate that blueberry supplementation led to global changes in the gut microbiome, which could possibly contribute to physiological changes in mice
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
1 Sample
Download data: BIOM, TXT
Series
Accession:
GSE161772
ID:
200161772
13.

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; mouse gut metagenome
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL21493 GPL22735
60 Samples
Download data
Series
Accession:
GSE133257
ID:
200133257
14.

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (16S rNA-seq)

(Submitter supplied) The colon contains a dense metabolically potent microbiota. The colonic O-glycan-rich mucus has been recognized as a key barrier to prevent microbial intrusion, but how this system forms and functions remains unclear. Here, we discovered that the colon mucus is mainly forged by microbiota-dependent secretion of O-glycosylated Muc2 by goblet cells in the ascending colon, where it seamlessly encapsulates the fecal materials including the microbiota. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL22735
30 Samples
Download data: TXT
Series
Accession:
GSE133256
ID:
200133256
15.

Dysbacteriosis-induced LPS elevation disturbs the development of muscle progenitor cells by interfering with retinoic acid signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
mouse gut metagenome; Gallus gallus
Type:
Other; Expression profiling by high throughput sequencing
Platforms:
GPL27659 GPL23499
13 Samples
Download data: FNA
Series
Accession:
GSE139526
ID:
200139526
16.

Dysbacteriosis-induced LPS elevation disturbs the development of muscle progenitor cells by interfering with retinoic acid signaling [16S rRNA sequencing]

(Submitter supplied) Whether myogenesis is affected by the maternal gut dysbacteriosis still remains ambiguous. In this study, firstly we show elevated level of lipopolysaccharides (LPS) in a gut microbiota dysbiosis mouse model. Secondly, we demonstrate that the diameter of muscle fibres, limb development and somitogenesis were inhibited in both gut microbiota dysbiosis and LPS exposed mice and chicken embryos. These might be due to LPS disturbed the cell survival and the key genes which regulating the somitogenesis and myogenesis. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL27659
7 Samples
Download data: FNA, TXT
Series
Accession:
GSE139422
ID:
200139422
17.

Bazedoxifene and conjugated estrogen combination improves gut-liver axis health [microbiota]

(Submitter supplied) Bazedoxifene and conjugated estrogens (CE+BZA) combination has been shown to prevent visceral adiposity and weight gain after menopause. However, its interaction with the microbiota has yet to be examined. In the present study, we use several –omics technologies to characterize the effects of various estrogens on the health of gut-liver axis. As reported in previous studies, CE+BZA combination is very effective at preventing ovariectomy-induced weight gain in mice fed a high-fat diet. more...
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
68 Samples
Download data: TXT
Series
Accession:
GSE93096
ID:
200093096
18.

Gut dysbiosis modulates the immune response to factor VIIII in murine hemophilia A

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; mouse gut metagenome
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL19964 GPL21051
29 Samples
Download data: RCC
Series
Accession:
GSE138332
ID:
200138332
19.

Ampicillin treatment casues dysbiosis that persists until study endpoint [RNA-seq]

(Submitter supplied) The development of neutralizing FVIII antibodies is the most serious complication of hemophilia A treatment. The currently known patient- and treatment-related risk factors for inhibitor development do not accurately predict this adverse event in all patients. The composition of the gut microbiota has been shown to influence immune mediated diseases at distant anatomical sites (e.g. lungs, brain and joints). more...
Organism:
mouse gut metagenome
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21051
17 Samples
Download data: CSV
Series
Accession:
GSE138330
ID:
200138330
20.

16s rDNA-sequencing of gastric flora in mice fed with high-salt diets

(Submitter supplied) There are 10 mice in the experiment, named REC. The mice were fed with high salt diets (5% NaCl) for 4 weeks and then fed with normal salt diets for 4 weeks. Then extracted DNA from mice gastric flora to detect changes in the gastric flora of mice.
Organism:
mouse gut metagenome
Type:
Other
Platform:
GPL21051
10 Samples
Download data: TXT
Series
Accession:
GSE134237
ID:
200134237
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