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Items: 16

1.

Selective reactivation of human X-linked genes in female fibroblasts reprogrammed by cell fusion

(Submitter supplied) In female mammals, one of the two X chromosomes is silenced as pluripotent cells differentiate. This process, termed X-inactivation, is random and results in mosaic expression of many X-linked genes in female tissues. Although X-inactivation can be reversed in vitro by reprogramming, the extent varies according to species, operator and conditions. Here, we have reprogrammed cloned female human fibroblasts by fusing them with mouse ESCs and examined the kinetics of X-linked gene re-expression. more...
Organism:
Homo sapiens x Mus musculus hybrid cell line; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL19068
15 Samples
Download data: XLSX
Series
Accession:
GSE60308
ID:
200060308
2.

Cell fusion-mediated pluripotent reprogramming triggers ordered changes in chromatin and gene expression across the human inactive X chromosome

(Submitter supplied) Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic reprogramming in mouse, but human studies are hampered by Xi epigenetic instability and difficulties in tracking partially reprogrammed iPSCs. Here we used cell fusion to examine the earliest events in the reprogramming-induced Xi reactivation of human female fibroblasts. more...
Organism:
Homo sapiens; Homo sapiens x Mus musculus hybrid cell line
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL19068
4 Samples
Download data: TXT
Series
Accession:
GSE77443
ID:
200077443
3.

Illumina HiSeq 2500 (Homo sapiens x Mus musculus hybrid cell line)

Organism:
Homo sapiens x Mus musculus hybrid cell line
2 Series
13 Samples
Download data
Platform
Accession:
GPL19068
ID:
100019068
4.

Clone 34 day6 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day6
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470730
ID:
301470730
5.

Clone 34 day4 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day4
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470729
ID:
301470729
6.

Clone 34 day4 Replicate 1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day4
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470728
ID:
301470728
7.

Clone 34 day0 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day0
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470727
ID:
301470727
8.

Clone 34 day0 Replicate 1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day0
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470726
ID:
301470726
9.

Clone 12 day6 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day6
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470723
ID:
301470723
10.

Clone 12 day6 Replicate 1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day6
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470722
ID:
301470722
11.

Clone 12 day4 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day4
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470721
ID:
301470721
12.

Clone 12 day4 Replicate 1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day4
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470720
ID:
301470720
13.

Clone 12 day0 Replicate 2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day0
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470719
ID:
301470719
14.

Clone 12 day0 Replicate 1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion_day0
Platform:
GPL19068
Series:
GSE60308
Download data
Sample
Accession:
GSM1470718
ID:
301470718
15.

Clone 34 day5 Replicate2

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion
Platform:
GPL19068
Series:
GSE77443
Download data
Sample
Accession:
GSM2051887
ID:
302051887
16.

Clone 34 day5 Replicate1

Organism:
Homo sapiens x Mus musculus hybrid cell line
Source name:
hF x mESC fusion
Platform:
GPL19068
Series:
GSE77443
Download data
Sample
Accession:
GSM2051886
ID:
302051886
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