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Items: 1 to 20 of 148822

1.

Cortical stimulation-based transcriptome shifts on Parkinson's disease animal model

(Submitter supplied) Parkinson's disease is the second most prevalent neurodegenerative disorder, characterized by the degeneration of dopaminergic neurons. Significant improvements in gait balance, particularly step length and velocity, were revealed by less-invasive wireless cortical stimulation. Transcriptome sequencing was performed to demonstrate the cellular mechanism, specifically targeting the primary motor cortex where the stimulation was applied. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
12 Samples
Download data: TXT
Series
Accession:
GSE271930
ID:
200271930
2.

Mild hyperuricemia and salt-sensitive hypertension

(Submitter supplied) Increased plasma uric acid (hyperuricemia) has been associated with worse outcomes for chronic kidney disease (CKD). But some attempts to control uric acid (UA) in large-cohort clinical trials did not produce clinically meaningful benefits for CKD. Some studies suggest that only hyperuricemia with crystals, but not asymptomatic hyperuricemia promotes the progression of CKD. Salt-sensitivity (SS) in blood pressure is a prevalent trait that is sexually dimorphic and results in kidney damage. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
10 Samples
Download data: TXT
Series
Accession:
GSE269511
ID:
200269511
3.

snRNA-seq dataset for "Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward"

(Submitter supplied) This dataset contains single-nucleus RNA-seq results from rat adult nucleus accumbens tissue treated with CRISPRi machinery (hSyn-driven dCas9-KRAB-MeCP2 fusion) with a CRISPR sgRNA targeting lacZ (a bacterial gene not found in the mammalian genome; used as a non-targeting control) or Reln.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
8 Samples
Download data: MTX, TSV
Series
Accession:
GSE269490
ID:
200269490
4.

RNA-seq dataset for "Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward"

(Submitter supplied) This dataset contains RNA-seq results from rat embryonic striatal neuronal cultures treated with CRISPRi machinery (dCas9-KRAB-MeCP2 fusion) with a CRISPR sgRNA targeting lacZ (a bacterial gene not found in the mammalian genome; used as a non-targeting control) or Reln.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
8 Samples
Download data: TXT
Series
Accession:
GSE269366
ID:
200269366
5.

Transcriptomic analysis of pulmonary vein under pathological pulmonary vein stenosis

(Submitter supplied) We reported the RNAseq analyses of pulmonary vein tissues at the age of postnatal day 21 (P21) on SD rats with or without pulmonary vein stenosis. Pulmonary vein stenosis was induced by performing pulmonary vein banding surgery within 24 hours postnatally. RNAseq analyses of the pulmonary vein tissues was generated at P21 from 3 sham-operated rats and 3 pulmonary vein banding rats. The results revealed that there were 1124 differentially expressed genes between PAB and sham group at P7, among which 714 were upregulated and 410 were downregulated.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
6 Samples
Download data: TXT
Series
Accession:
GSE267175
ID:
200267175
6.

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL30293 GPL22760
16 Samples
Download data: TXT
Series
Accession:
GSE209831
ID:
200209831
7.

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]

(Submitter supplied) To investigate the repair mechanism of urethral wound after prostatectomy, we used microarray RNA sequences and bioinformatics methods to analyze the entire transcriptome of post-urethral resection trauma tissue in the rat prostate.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL22760
8 Samples
Download data: TXT
Series
Accession:
GSE209829
ID:
200209829
8.

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]

(Submitter supplied) To investigate the repair mechanism of urethral wound after prostatectomy, we used microarray RNA sequences and bioinformatics methods to analyze the entire transcriptome of post-urethral resection trauma tissue in the rat prostate.
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL30293
8 Samples
Download data: TXT
Series
Accession:
GSE209827
ID:
200209827
9.

Expression Profiling of Heart (NH, TAC and TAC-R)

(Submitter supplied) Transcriptome analysis of RNA samples from whole heart Transverse aortic constriction (TAC) is a well-established method for studying the pathomechanisms of heart failure in animal models of cardiac hypertrophy. A number of studies have shown that the treatment of heart failure in this animal model of cardiac hypertrophy suggests that hypertrophy and fibrosis may be reversible. However, since TAC-release protocols that improve hemodynamics by releasing physical stenosis remain undefined, the histological characteristics and molecular biological regulatory mechanisms of the reversibility of cardiac hypertrophy and fibrosis are unknown. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL23040
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE270186
ID:
200270186
10.

microRNA expression data of ascencding central auditory pathway from noise-induced hearing loss rat model

(Submitter supplied) 115 dB SPL of noise exposure for 2 hours causes high threshold shift at day 1 and recovers rapidly at day 3. Microarray was performed to identify up or down-regulated genes during rapid recovery of hearing.
Organism:
synthetic construct; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL19117
64 Samples
Download data: CEL
Series
Accession:
GSE271449
ID:
200271449
11.

RNA-seq analysis evaluating effects of Adssl1 overexpression in neonatal rat ventricular myocytes (NRVM)

(Submitter supplied) Reactivating cell cycle re-entry in adult cardiomyocytes improves cardiac function after myocardial infarction (MI). De novo purine synthesis is a critical source of nucleotides and is involved in modulating cell proliferation. Here, using gain-of-function genetic tools, we explored the role of the de novo purine synthesis enzyme Adssl1 in cardiac regeneration. RNA sequencing analysis suggested that Adssl1 overexpression induced strong dedifferentiation and cell cycle entry.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24782
7 Samples
Download data: TXT
Series
Accession:
GSE271411
ID:
200271411
12.

Differences in the tRF & tiRNA Profiles of Sperm after Neonatal Sevoflurane Exposure

(Submitter supplied) The ncRNAs derived from transfer RNAs (tRNAs), such as tRFs (tRNA-derived fragments) and tiRNAs (tRNA halves), play crucial roles in sperm development, maturation, and function, ultimately affecting the health of offspring. To further elucidate the changes in sperm tRF & tiRNA profiles induced by neonatal sevoflurane exposure, we collected sperm from the caudal epididymis of rats and isolated total RNA for tRF & tiRNA sequencing.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20084
4 Samples
Download data: XLSX
Series
Accession:
GSE271145
ID:
200271145
13.

Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA

(Submitter supplied) Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease caused by a polyglutamine (polyQ)-encoding CAG repeat expansion in the androgen receptor (AR) gene, leading to AR aggregation, lower motor neuron death, and muscle atrophy. AR is a ligand-activated transcription factor that regulates neuronal architecture and promotes axon regeneration; however, whether AR transcriptional functions contribute to disease pathogenesis is not fully understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22396
12 Samples
Download data: CSV, TXT
Series
Accession:
GSE267802
ID:
200267802
14.

Dor regulates alpha-KG metabolic pathways in mature oligodendrocytes to enhance myelination and reverse age-related remyelination decline [CUT&Tag]

(Submitter supplied) Impairment of oligodendrocyte (OL) myelinogenic potential, rather than inability of oligodendrocyte precursors to differentiate, is implicated in remyelination failure in demyelinating diseases such as multiple sclerosis. However, the mechanisms underlying myelinogenesis and age-related decline in remyelination remain elusive. Here, we identify a mature-OL-active transcriptional regulator Dor as a critical mediator of CNS myelination and remyelination. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25947
3 Samples
Download data: BIGWIG, NARROWPEAK
Series
Accession:
GSE233591
ID:
200233591
15.

Dor regulates alpha-KG metabolic pathways in mature oligodendrocytes to enhance myelination and reverse age-related remyelination decline

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL25947
9 Samples
Download data: BIGWIG, NARROWPEAK, RESULTS
Series
Accession:
GSE233593
ID:
200233593
16.

Innate immune activation modulates contractile and electrical dysfunction in engineered heart tissue models fordesmoplakin(DSP)cardiomyopathy.

(Submitter supplied) Desmosomes are specialized cell-cell junctions critically important in the heart, where their disruption promotes arrhythmogenic cardiomyopathy (ACM). Individuals carrying truncating variants in the desmosomal gene desmoplakin (DSP) often show a prominent inflammatory component in the absence of known antigenic stimuli, termed “hot phase” arrythmia. To assess the role of innate immune activation in DSP-cardiomyopathy, we generated engineered heart tissues (EHTs) from two patients with heterozygous DSP truncation variants (DSPtv, p.E1597X and p.R1951X). more...
Organism:
Rattus norvegicus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL22396
30 Samples
Download data: TXT
Series
Accession:
GSE248187
ID:
200248187
17.

The miRNA profiles of amniotic fluid-derived extracellular vesicles and fetal lung tissue of nitrofen-induced congenital diaphragmatic hernia rat model.

(Submitter supplied) Congenital diaphragmatic hernia (CDH) is a life-threatening anomaly with high morbidity and mortality. To investigate the pathogenesis of CDH, miRNA sequencing was performed using amniotic fluid-derived extracellular vesicles (AF-EVs) and fetal lung tissue of nitrofen-induced CDH rat model.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL19052
30 Samples
Download data: TXT
Series
Accession:
GSE240558
ID:
200240558
18.

Facile Osteoimmunomodulatory Nanoparticles Augment 3D-Printed Scaffold-Mediated Bone Regeneration

(Submitter supplied) Regenerating critical-sized long bone defects poses substantial challenges due to limitations of autografts and processed allografts. Biomaterial scaffolds offer versatile alternatives, yet their effectiveness is often constrained by their limited innate osteoinductivity. While growth factors and cells can enhance osteoinduction, the inclusion of biologics in biomaterial scaffolds creates regulatory challenges for clinical translation. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
18 Samples
Download data: TXT
Series
Accession:
GSE262295
ID:
200262295
19.

DNA hydrogel based Wound Hemostatic Adjuvant

(Submitter supplied) Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention to stop bleeding plays as a critical role in saving lives. However, rapid hemostasis in deep non-compressible trauma using a highly water-absorbent hydrogel, combined with strong tissue adhesion and bionic procoagulant mechanism, remains a challenge. In this study, a DNA hydrogel (DNAgel) network composed of natural nucleic acids with rapid water absorption, high swelling and instant tissue adhesion is reported, like a “band-aid” to physically stop bleeding. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22396
9 Samples
Download data: XLSX
Series
Accession:
GSE268849
ID:
200268849
20.

Activation of S1P2 is protective against cisplatin-induced peripheral neuropathy

(Submitter supplied) To elucidate the molecular mechanisms underlying the neuroprotective role of S1P2, we conduct RNASeq on dorsal root ganglions (DRGs) collected from a cisplatin-induced peripheral neuropathy (CIPN) rat model.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
12 Samples
Download data: TXT
Series
Accession:
GSE235877
ID:
200235877
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