fasting-induced adipose factor - GEO DataSets

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Items: 3

Select item 2001999631.

p53 regulates a miRNA-fructose transporter axis in brown adipose tissue under fasting

(Submitter supplied) Active thermogenic adipocytes voraciously consume energy substrates like fatty acids and glucose to maintain body temperature upon cold exposure. Despite strong evidence for the involvement of brown adipose tissue (BAT) in controlling systemic energy homeostasis upon nutrient excess, it is unclear how the activity of brown adipocytes is regulated in times of nutrient scarcity. Therefore, this study aimed to scrutinize factors that modulate BAT activity to balance thermogenic and energetic needs upon simultaneous fasting and cold-exposure. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE199963

ID:: 200199963

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000596442.

Insights into microbial modulation of host peripheral lipid and glucose metabolism using mouse gut organoids

(Submitter supplied) The gastrointestinal microbiota is involved in the development of various diseases, such as obesity and diabetes, by affecting nutrient acquisition, energy balance, and metabolic signaling of the host. However, the underlying mechanisms of these host-microbiota interactions remain unclear. The aim of this study was to characterize effects of the microbiota on the host epithelium using a novel gastrointestinal model based on mouse organoids. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
32 Samples

Download data: TXT

Series

Accession:: GSE59644

ID:: 200059644

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000436583.

Transcriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue

(Submitter supplied) Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that the genetic inactivation of transcriptional co-factor transducin beta-like-related (TBLR) 1 blunts the lipolytic response of white adipocytes through the impairment of cAMP-dependent signal transduction. more...