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Items: 4

1.

Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL9250 GPL13112 GPL1261
22 Samples
Download data: CEL, TXT
Series
Accession:
GSE40686
ID:
200040686
2.

Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]

(Submitter supplied) Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new enhancers or by exploiting a pre-existing enhancer landscape. Analysis of the chromatin accessibility of Foxp3-bound enhancers in Treg and Foxp3-negative T cells showed that Foxp3 was bound overwhelmingly to pre-accessible enhancers occupied by its cofactors in precursor cells or a structurally related predecessor. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL13112
11 Samples
Download data: TXT
Series
Accession:
GSE40684
ID:
200040684
3.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
4.

Treg Foxp3 ChIP Rep1 (Tech Rep2)

Organism:
Mus musculus
Source name:
Treg Foxp3 ChIP
Platform:
GPL13112
Series:
GSE40684 GSE40686
Download data
Sample
Accession:
GSM999180
ID:
300999180
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Supplemental Content

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