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Items: 3

1.

FLT3 activation cooperates with MLL-AF4 fusion gene to abrogate the hematopoietic specification of human ESCs

(Submitter supplied) MLL-AF4 is a hallmark genomic aberration which arises prenatally in high-risk infant acute lymphoblastic leukemia (ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hemato-endothelial specification but was not sufficient for transformation. Additional cooperating genetic insults seem required for MLL-AF4-mediated leukemogenesis. FLT3 is highly expressed in MLL-AF4+ ALL through activating mutations (FLT3-TKD or FLT3-ITD) or increased transcriptional expression, being therefore considered a potential cooperating event in MLL-AF4+ ALL. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
18 Samples
Download data: TXT
Series
Accession:
GSE40103
ID:
200040103
2.

Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)

(Submitter supplied) SurePrint G3 Human GE 8x60K Microarray Arrays of this design have barcodes that begin with 16028004 or 2528004. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...
Organism:
Homo sapiens
233 Series
2 Related Platforms
3749 Samples
Download data: TXT
Platform
Accession:
GPL13607
ID:
100013607
3.

CD45- hemogenic precursors FLT3-TKD/MLLAF4 rep2

Organism:
Homo sapiens
Source name:
CD45- hemogenic precursors FLT3-TKD/MLLAF4 rep2
Platform:
GPL13607
Series:
GSE40103
Download data: TXT
Sample
Accession:
GSM984953
ID:
300984953
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