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Items: 4

1.

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line

(Submitter supplied) Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length CFTR protein. The deltaF508 mutation results in a mutant protein that is degraded by the proteasome instead of progressing to the apical membrane where it functions as a cyclic AMP-regulated chloride channel. 4 phenylbutyrate modulates heat shock protein expression and promotes trafficking of deltaF508 thus permitting maturation and membrane insertion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS493 GDS494
Platforms:
GPL96 GPL97
22 Samples
Download data: CEL
Series
Accession:
GSE620
ID:
200000620
2.
Full record GDS493

Cystic fibrosis pathology and 4-phenylbutyrate (HG-U133A)

Effect of 1mM 4-phenylbutyrate (PBA) at 0, 12 and 24 hours in cystic fibrosis bronchial epithelial model cell line IB3-1. PBA modulates heat shock protein and promotes trafficking of deltaF508 cystic fibrosis transmembrane conductance regulator (CFTR).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 time sets
Platform:
GPL96
Series:
GSE620
11 Samples
Download data: CEL
DataSet
Accession:
GDS493
ID:
493
3.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...
Organism:
Homo sapiens
364 DataSets
1125 Series
11 Related Platforms
42430 Samples
Download data
Platform
Accession:
GPL96
ID:
100000096
4.

0 hr Ctl A-chip 6-11-02

Organism:
Homo sapiens
Source name:
IB3-1 bronchial epithelial cell line
Platform:
GPL96
Series:
GSE620
Dataset:
GDS493
Download data: CEL
Sample
Accession:
GSM9516
ID:
300009516
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db=gds|term=GSM9516[Accession]|query=1|qty=2|blobid=MCID_662635db4c13c13a06800124|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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