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Items: 4

1.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
25 related Platforms
993 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT
Series
Accession:
GSE51334
ID:
200051334
2.

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(Submitter supplied) Short nascent strands purification coupled to next-generation sequencing allowed us to identify replication origins on human genome in an extensive way, by mapping replication origins in 4 different cell types, IMR-90 fibroblasts, hESC H9 cells, iPSC Th Cl-4 cells and HeLa cells. We demonstrated the existence of a cell type-specific reprogrammable signature of the cell identity revealed by specific efficiencies of conserved origin positions and not by the selection of cell-type specific subsets of origins.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
4 Samples
Download data: BED
Series
Accession:
GSE37757
ID:
200037757
3.

Illumina Genome Analyzer II (Homo sapiens)

Platform
Accession:
GPL9115
ID:
100009115
4.

IMR-90

Organism:
Homo sapiens
Source name:
embryonic lung fibroblasts
Platform:
GPL9115
Series:
GSE37757 GSE51334
Download data: BED
Sample
Accession:
GSM927235
ID:
300927235
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Supplemental Content

db=gds|term=GSM927235[Accession]|query=1|qty=3|blobid=MCID_66491932f630692827498123|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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