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Items: 3

1.

Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer

(Submitter supplied) KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and amplifications of KRASG12C, MYC, MET, EGFR, and CDK6 emerged at acquired resistance. In PDAC cell lines and organoid models treated with the KRASG12D inhibitor MRTX1133, epithelial-to-mesenchymal transition and PI3K-AKT-mTOR signaling associate with resistance to therapy. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
17 Samples
Download data: RDS
Series
Accession:
GSE269313
ID:
200269313

PubMed Similar studies

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
13444 Series
684249 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

KPC_3716, Vehicle, snRNAseq

Organism:
Mus musculus
Source name:
Pancreatic ductal adenocarcinoma
Platform:
GPL24247
Series:
GSE269313
Download data: RDS
Sample
Accession:
GSM8312891
ID:
308312891

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db=gds|term=GSM8312891[Accession]|query=1|qty=2|blobid=MCID_66e37a1bf5aadd3332492a86|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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