GSM8226610[Accession] - GEO DataSets

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Items: 4

Select item 2002647301.

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL24676 GPL24247 GPL18573
203 Samples

Download data: COV

Series

Accession:: GSE264730

ID:: 200264730

Select item 2002647222.

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [RRBS]

(Submitter supplied) Isocitrate Dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores anti-tumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. more...