GSM8186173[Accession] - GEO DataSets

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Items: 4

Select item 2002631241.

Molecular Basis for Differential Igk Versus Igh V(D)J Joining Mechanisms

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other

Platforms:: GPL30172 GPL21626
124 Samples

Download data: BEDGRAPH, TLX

Series

Accession:: GSE263124

ID:: 200263124

PubMed Full text in PMC Similar studies

Select item 2002631232.

Molecular Basis for Differential Igk Versus Igh V(D)J Joining Mechanisms [3C-HTGTS data]

(Submitter supplied) In developing B lymphocytes, V(D)J recombination assembles IgH and Igk variable region exons from hundreds of gene segments clustered across mega-base Igh and Igk loci. V, D, and J segments are flanked by conserved recombination signal sequences (RSSs) that target RAG endonuclease. RAG orchestrates Igh V(D)J recombination upon capturing a JH-RSS within the JH-RSS-based recombination center (RC). JH-RSS orientation programs RAG to scan upstream D- and VH-containing chromatin linearly presented by cohesin-mediated loop extrusion. more...