GSM8111835[Accession] - GEO DataSets

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Items: 3

Select item 2002592361.

Common modes of ERK induction resolve into context specific signalling via a combination of signal duration and cell type specific transcriptional repression [E5.5_RNA]

(Submitter supplied) Fibroblast Growth Factor (FGF) signalling via ERK exerts diverse roles in development and disease. In mammalian preimplantation embryos and naïve pluripotent stem cells ERK promotes differentiation, whereas in primed pluripotent states closer to somatic differentiation ERK sustains self-renewal. How can the same pathway produce different outcomes in two related cell types? To explore context-dependent ERK signalling in embryonic development and differentiation we generated cell and mouse lines that allow for tissue- and time-specific cell intrinsic ERK activation. more...