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Items: 4

1.

Caspase-1 deficiency reduces intestinal and hepatic triglyceride-rich lipoprotein secretion

(Submitter supplied) Background and Aims: Inflammasome-mediated caspase-1 activity regulates the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1ß and IL-18. Recently, we showed that caspase-1 deficiency strongly reduces high fat diet-induced adiposity although the mechanism is still unclear. We now aimed to elucidate the mechanism by which caspase-1 deficiency reduces modulates resistance to high fat diet-feeding fat accumulation in adipose tissue by focusing on the role of caspase-1 in the regulation of triglyceride (TG)-rich lipoprotein metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4922 GDS6176
Platform:
GPL11533
24 Samples
Download data: CEL
Series
Accession:
GSE32515
ID:
200032515
2.
Full record GDS6176

Caspase-1 deficiency effect on lipid-loaded intestines

Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 3 tissue sets
Platform:
GPL11533
Series:
GSE32515
18 Samples
Download data: CEL
3.

[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html MoGene-1_1-st-v1.na31.mm9.transcript.csv #%create_date=Fri Aug 27 17:50:02 2010 PDT #%chip_type=MoGene-1_1-st-v1 #%lib_set_name=MoGene-1_1-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07-00 #%genome-lifted-method=liftOver #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm8 #%genome-lifted_from-version-ncbi=36 #%netaffx-annotation-date=2010-07-15 #%netaffx-annotation-netaffx-build=31 Protocol: see manufacturer's web site
Organism:
Mus musculus
10 DataSets
174 Series
7 Related Platforms
4230 Samples
Download data
Platform
Accession:
GPL11533
ID:
100011533
4.

duodenum_WT_repl1

Organism:
Mus musculus
Source name:
duodenum from wild type mouse (C57BL/6), maintained on chow, 2hrs after lipid load, replicate 1
Platform:
GPL11533
Series:
GSE32515
Dataset:
GDS6176
Download data: CEL
Sample
Accession:
GSM805237
ID:
300805237
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db=gds|term=GSM805237[Accession]|query=1|qty=2|blobid=MCID_666d86286e9d376f23481573|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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