GSM7993285[Accession] - GEO DataSets

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Items: 4

Select item 2002520711.

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Bacteria; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21626 GPL24661
18 Samples

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Accession:: GSE252071

ID:: 200252071

PubMed Full text in PMC Similar studies

Select item 2002520692.

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β [RNA-Seq]

(Submitter supplied) Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β). However, the role of IL-1β in intestinal defense against Salmonella remains unclear. Here, we show that IL-1b production is detrimental during Salmonella infection. Mice lacking IL-1b (IL-1b -/-) failed to recruit neutrophils to the gut during infection, which reduced tissue damage and prevented depletion of short-chain fatty acid-producing commensals. more...