GSM797705[Accession] - GEO DataSets

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Items: 4

Select item 2000336931.

Selective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL9250
31 Samples

Download data: BAM, BEDGRAPH, BIGWIG, SAM, TXT

Series

Accession:: GSE33693

ID:: 200033693

PubMed Full text in PMC Similar studies

Select item 2000321902.

Selective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros (RNA-seq: Thymocytes)

(Submitter supplied) The C2H2 zinc finger is the most prevalent DNA-binding motif in the mammalian proteome, with DNA-binding domains usually containing more tandem fingers than are needed for stable sequence-specific DNA recognition. To examine the reason for the frequent presence of multiple zinc fingers, we generated mice lacking finger 1 or finger 4 of the 4-finger DNA-binding domain of Ikaros, a critical regulator of lymphopoiesis and leukemogenesis. more...