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Items: 4

1.

Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Other; Expression profiling by high throughput sequencing
Platforms:
GPL30173 GPL24247 GPL11154
47 Samples
Download data: DCC, H5, RESULTS
Series
Accession:
GSE249541
ID:
200249541
2.

Extracellular niche and tumor microenvironment enhance the impact of KRAS inhibitors in pancreatic cancer models [CRISPR]

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which new therapeutic interventions are needed. Here, we assessed the cellular response to pharmacological KRAS inhibition, targeting the central oncogenic factor in PDAC. In a panel of PDAC cell lines, pharmaceutical inhibition of the KRASG12D allele with MRTX1133 yields variable efficacy in the suppression of cell growth and downstream gene expression programs in 2D culture. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL30173
10 Samples
Download data: TXT
Series
Accession:
GSE249537
ID:
200249537
3.

NextSeq 2000 (Homo sapiens)

Platform
Accession:
GPL30173
ID:
100030173
4.

UM53-TKO-DMSO-P8

Organism:
Homo sapiens
Source name:
UM53
Platform:
GPL30173
Series:
GSE249537 GSE249541
Download data
Sample
Accession:
GSM7949443
ID:
307949443
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Supplemental Content

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