GSM7908369[Accession] - GEO DataSets

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Items: 4

Select item 2002482071.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247
42 Samples

Download data: BROADPEAK

Series

Accession:: GSE248207

ID:: 200248207

PubMed Full text in PMC Similar studies

Select item 2002482062.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [ATAC-Seq]

(Submitter supplied) Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform into SCLC following treatment with targeted therapies. Here we designed models to follow the conversion of LUAD to SCLC and found the barrier to histological transformation converges on tolerance to Myc, which we implicate as a lineage-specific driver of the pulmonary neuroendocrine cell. more...