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Items: 4

1.

Unfolded protein Response is a major hurdle in direct neuronal reprogramming of human astrocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL18460 GPL24676
71 Samples
Download data
Series
Accession:
GSE248129
ID:
200248129
2.

Unfolded protein Response is a major hurdle in direct neuronal reprogramming of human astrocytes [Bulk RNA-seq]

(Submitter supplied) Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but almost nothing is known about the impact of mitochondrial dysfunction in human cell direct reprogramming. Here we explore the defects and how to improve the neuronal reprogramming of iPSC-derived astrocytes carrying mutations in NDUFS4 gene, important for Complex I and associated to Leigh Sydrome. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
55 Samples
Download data: CSV
Series
Accession:
GSE248120
ID:
200248120
3.

Illumina HiSeq 1500 (Homo sapiens)

Platform
Accession:
GPL18460
ID:
100018460
4.

control_ULERi82a-R1-002_nonpAstro_3

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL18460
Series:
GSE248120 GSE248129
Download data
Sample
Accession:
GSM7906124
ID:
307906124
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Supplemental Content

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