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Items: 4

1.

A genetically engineered mouse model of NUT carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL24676
76 Samples
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Series
Accession:
GSE241477
ID:
200241477
2.

A genetically engineered mouse model of NUT carcinoma (CUT&RUN)

(Submitter supplied) We created a genetically engineered mouse model (GEMM) of NC that forms a Brd4-NUTM1 fusion gene upon tamoxifen-induction of Sox2-driven Cre. Two GEMM-derived cell lines were developed whose transcriptomic and epigenetic landscapes, characterized by RNAseq and CUT&RUN, show striking overlap with those of primary GEMM tumors. GEMM primary tumor and cell lines form very large H3K27ac-enriched super-enhancers that are unique to hNC, termed megadomains, that are invariably associated with key hNC-defining transcriptional oncogenic targets, Myc and Trp63.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL24247
55 Samples
Download data: TDF
Series
Accession:
GSE241476
ID:
200241476
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

311E cell line H3K27me3 96hr IgG rep 2 Experiment 2

Organism:
Mus musculus
Source name:
311E cell line
Platform:
GPL24247
Series:
GSE241476 GSE241477
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Sample
Accession:
GSM7823544
ID:
307823544
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Supplemental Content

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