GSM7806570[Accession] - GEO DataSets

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Items: 3

Select item 2002440951.

Antiepileptic medication induces homeostatic synaptic plasticity in pyramidal neurons of the adult human neocortex

(Submitter supplied) Homeostatic synaptic plasticity serves to maintain neuronal function within a dynamic range, compensating for perturbations in network activity. While coordinated structural and functional changes at synaptic sites play a crucial role in adaptive processes, the specific regulatory mechanisms and biological relevance of homeostatic plasticity in the human brain warrant further investigation. In this study, we investigated the effects of neural network silencing, achieved through pharmacological inhibition of voltage-gated sodium channels or glutamatergic neurotransmission – common targets of antiepileptic medication – on functional and structural properties of murine and human cortical tissue. more...