GSM7798780[Accession] - GEO DataSets

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Items: 4

Select item 2002439461.

Deletion of Klotho enhancer deepens sexual dimorphism of gene expression without impacting female resistance to kidney injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL21493 GPL24247
37 Samples

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Accession:: GSE243946

ID:: 200243946

PubMed Full text in PMC Similar studies

Select item 2002439442.

Deletion of Klotho enhancer deepens sexual dimorphism of gene expression without impacting female resistance to kidney injury [ChIP]

(Submitter supplied) Sexual dimorphism in kidney injury markers, such as Klotho, is frequently underestimated or disregarded, as most of the preclinical research is done in male animals. Klotho is well-linked to renal health and its deletion in mice results in a severe accelerated aging-like phenotype and premature death. Here, we identified candidate Klotho enhancers and discovered their function using mice carrying deletions in the enhancer loci. more...