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Items: 3

1.

Altered tumor signature and T-cell profile after chemotherapy reveal new therapeutic opportunities in High-Grade Serous Ovarian Carcinoma

(Submitter supplied) Using single-cell RNA sequencing, we assessed the systemic impact of chemotherapy on tumor, stromal, and immune cells in the high-grade serous ovarian carcinoma. The results reveal remodeling of the T cell profiles towards a more naïve state and the upregulation of the epithelial-mesenchymal transition signatures in surviving tumor cells. These alterations suggest cellular and molecular targets for the therapeutic development in chemotherapy-resistant ovarian cancer.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Third-party reanalysis
Platform:
GPL16791
11 Samples
Download data: CSV, RDS
Series
Accession:
GSE241221
ID:
200241221
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

ovCHA017, scTCR-seq

Organism:
Homo sapiens
Source name:
Ovary
Platform:
GPL16791
Series:
GSE241221
Download data: CSV
Sample
Accession:
GSM7719628
ID:
307719628
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