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Items: 3

1.

PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma

(Submitter supplied) Despite the immense success of immune checkpoint blockade (ICB) in cancer treatment, many tumors, including melanoma, exhibit innate or adaptive resistance. Tumor-intrinsic T-cell deficiency and T-cell dysfunction have been identified as essential factors in the emergence of ICB resistance. Here, we found that protein arginine methyl transferase 1 (PRMT1) expression was inversely correlated with the number and activity of CD8+ T cells within melanoma specimen. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL24676
20 Samples
Download data: BW, GTF, TXT
Series
Accession:
GSE240258
ID:
200240258
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

B16_F10 cells, CTRL,rep3

Organism:
Mus musculus
Source name:
cell line
Platform:
GPL24247
Series:
GSE240258
Download data
Sample
Accession:
GSM7689123
ID:
307689123
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db=gds|term=GSM7689123[Accession]|query=1|qty=3|blobid=MCID_67b189aa1a48797f603b3320|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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