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Items: 4

1.

Breaking through NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL21103
35 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE236682
ID:
200236682
2.

Breaking through NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection [RNA-Seq 1]

(Submitter supplied) Melanomas are generated from melanocytes, the neural crest derivatives sharing a neuroectodermal origin with the nervous system. In investigating whether immune privilege of the nervous system might be exploited by melanoma, we found that nerve growth factor (NGF) exerts both melanoma cell-intrinsic and -extrinsic immunosuppression. In melanoma cells, autocrine NGF engages TrkA receptor to desensitize IFN-gamma signaling, leading to T and NK cell exclusion. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
8 Samples
Download data: TXT
Series
Accession:
GSE236673
ID:
200236673
3.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
4.

Nko2_1

Organism:
Mus musculus
Source name:
Melanoma cell line
Platform:
GPL21103
Series:
GSE236673 GSE236682
Download data
Sample
Accession:
GSM7567373
ID:
307567373
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db=gds|term=GSM7567373[Accession]|query=1|qty=2|blobid=MCID_67aa402c750a117a1d4d18a0|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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