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Items: 5

1.

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

(Submitter supplied) To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I–hypersensitive sites (DHSs) in 45 mouse cell and tissue types, and systematically compared these with human DHS maps from orthologous compartments. We found that the mouse and human genomes have undergone extensive cis-regulatory rewiring that combines branch-specific evolutionary innovation and loss with widespread repurposing of conserved DHSs to alternative cell fates, and that this process is mediated by turnover of transcription factor (TF) recognition elements. more...
Organism:
Mus musculus; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
5 related Platforms
266 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, WIG
Series
Accession:
GSE51336
ID:
200051336
2.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
25 related Platforms
993 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT
Series
Accession:
GSE51334
ID:
200051334
3.

DNaseI Hypersensitivity by Digital DNaseI from ENCODE/University of Washington

(Submitter supplied) This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Richard Sandstrom mailto:sull@u.washington.edu). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This track is produced as part of the ENCODE Project. This track shows DNaseI sensitivity measured genome-wide in different cell lines using the Digital DNaseI methodology (see below), and DNaseI hypersensitive sites. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9052 GPL9115
208 Samples
Download data: BAM, BIGWIG, BROADPEAK, NARROWPEAK
Series
Accession:
GSE29692
ID:
200029692
4.

Illumina Genome Analyzer II (Homo sapiens)

Platform
Accession:
GPL9115
ID:
100009115
5.

Stam_HUVEC_1

Organism:
Homo sapiens
Source name:
HUVEC
Platform:
GPL9115
Series:
GSE29692 GSE51334 GSE51336
Download data: BAM, BIGWIG, BROADPEAK, NARROWPEAK
Sample
Accession:
GSM736575
ID:
300736575
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db=gds|term=GSM736575[Accession]|query=1|qty=3|blobid=MCID_664ec28ffaf6612e8f27821d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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