GSM7305502[Accession] - GEO DataSets

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Items: 4

Select item 2002324901.

A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

5 related Platforms
120 Samples

Download data: BEDGRAPH, BW, HIC, TBI

Series

Accession:: GSE232490

ID:: 200232490

Select item 2002318802.

A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS [HiChIP_LpreB_Inducible]

(Submitter supplied) A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage-specific assembly of chromatin that supercedes these constraints is required to configure the genome to support the gene expression changes that guide faithful lineage progression. Using loss-of-function approaches in B cell precursors in vivo we show that IKAROS assembles interactions between sites often separated by megabase distances to configure a significant fraction of the genome in preparation for lymphoid development. more...