GSM7305323[Accession] - GEO DataSets

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Items: 4

Select item 2002318691.

Modulation of CTCF barrier permeability by ZFP661 enhances protocadherin diversity for proper cortical dendritic projection in mammals

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17021 GPL24247
90 Samples

Download data: BED, BW, NARROWPEAK, TAR, TXT

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Accession:: GSE231869

ID:: 200231869

Select item 2002318642.

Capture Hi-C in (EV and ZFP661-3HA OE) mESCs and E16.5 mouse forebrains

(Submitter supplied) This assay aimed to investigate the regulatory role of ZFP661 in modulating the permeability of CTCF barriers. To achieve this, we generated Capture Hi-C maps on several regions bound by ZFP661 using E16.5 forebrains from wild-type (WT) and Zfp661 knockout (KO) mice, as well as empty vector (EV) control and ZFP661-3HA overexpressing (OE) mESCs. Our findings reveal that ZFP661 modulates the permeability of CTCF barriers, thereby balancing between the interactions that are trapped at the barriers and those passing over them.