GSM7243459[Accession] - GEO DataSets

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Items: 4

Select item 2002308201.

Y chromosome loss in cancer drives growth by evasion of adaptive immunity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL21103
23 Samples

Download data: TXT

Series

Accession:: GSE230820

ID:: 200230820

PubMed Full text in PMC Similar studies

Select item 2002308192.

Y chromosome loss in bladder cancer contributes to T cell exhaustion and sensitivity to immune checkpoint blockade [WES]

(Submitter supplied) Loss of the Y chromosome (LOY) is observed in several common cancer types, including 10-40% of bladder cancers, but the clinical and biological significance of this finding is unknown. Through genomic and transcriptomic studies, we report that low LOY gene signature scores correlate with poor prognoses in patients with bladder cancer. We then performed in-depth studies of natural occurring bladder cancer cells with LOY mutants as well as those with targeted deletion of Y chromosome by CRISPR/Cas9. more...