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Items: 3

1.

Differential Effects of JAK1 vs. JAK2 Inhibition in Mouse Models of Hemophagocytic Lymphohistiocytosis

(Submitter supplied) Hemophagocytic lymphohistiocytosis (HLH) comprises a severe hyperinflammatory phenotype driven by the overproduction of cytokines, many of which signal via the JAK/STAT pathway. Indeed, the JAK1/2 inhibitor ruxolitinib has demonstrated efficacy in pre-clinical studies and early-phase clinical trials in HLH. Nevertheless, concerns remain for ruxolitinib-induced cytopenias, which are postulated to result from the blockade of JAK2-dependent hematopoietic growth factors. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
30 Samples
Download data: FA, TXT
Series
Accession:
GSE230771
ID:
200230771

PubMed Similar studies

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
15334 Series
710478 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

CD8_Prf1_Ruxo_3 2511416_15

Organism:
Mus musculus
Source name:
Blood
Platform:
GPL24247
Series:
GSE230771
Download data
Sample
Accession:
GSM7234104
ID:
307234104

SRA Run Selector

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db=gds|term=GSM7234104[Accession]|query=1|qty=2|blobid=MCID_678a6f6a2b88aa5f5d3394ea|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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