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Items: 4

1.

Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, bulk RNA-seq

(Submitter supplied) Glutamine metabolism in the tumor microenvironment is emerging as a critical regulator of immune-mediated anti-tumor responses. We report potent tumor growth inhibition by the glutamine antagonist prodrug JHU083 in urologic tumors by JHU083-reprogrammed tumor-associated macrophages (TAMs) and tumor-infiltrating monocytes (TIMs). Using orthogonal approaches, we show that JHU083-mediated glutamine antagonism in the tumor microenvironment induces TNF, inflammatory, and mTORC1 signaling in different intra-tumoral TAM clusters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: RESULTS, TXT
Series
Accession:
GSE229222
ID:
200229222
2.

Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: H5, RESULTS
Series
Accession:
GSE230162
ID:
200230162
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

Control, TAMs, mouse 959

Organism:
Mus musculus
Source name:
Sub-cutaneous tumor
Platform:
GPL24247
Series:
GSE229222 GSE230162
Download data: RESULTS
Sample
Accession:
GSM7157132
ID:
307157132
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db=gds|term=GSM7157132[Accession]|query=1|qty=2|blobid=MCID_67a63ea6750a117a1d9a5c52|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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