GSM7074123[Accession] - GEO DataSets

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Items: 4

Select item 2002263761.

The Triptryium wilfordii derivative celastrol has anti-fibrotic effects in systemic sclerosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL18573
24 Samples

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Series

Accession:: GSE226376

ID:: 200226376

PubMed Similar studies

Select item 2002263752.

The Triptryium wilfordii derivative celastrol has anti-fibrotic effects in systemic sclerosis [In vivo bulk RNA-seq]

(Submitter supplied) Objectives: Scleroderma (systemic sclerosis, SSc), as a prototypic inflammation-driven fibrotic disease, possesses connective tissue lesions populated with persistently activated myofibroblasts maintained by an mechanotranductive/pro-adhesive signaling loop. Drugs targeting this pathway are therefore of likely therapeutic benefit. The mechanosensitive transcriptional co-activator, yes activated protein-1 (YAP1), is activated in SSc fibroblasts. more...