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Items: 4

1.

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B-cell fate decisions and accelerates development of T-cell depleted lymphomas.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL24247 GPL24676
143 Samples
Download data: BIGWIG, BROADPEAK, BW, MTX, NARROWPEAK, TSV
Series
Accession:
GSE224513
ID:
200224513
2.

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B-cell fate decisions and accelerates development of T-cell depleted lymphomas [ATAC-seq]

(Submitter supplied) Mutations in chromatin modifiers are a hallmark of many tumors, especially lymphomas arising from germinal center (GC) B cells. Given that these lymphoma mutations all induce aberrant gene repression, it is surprising that they often co-occur in individual patients. The most common pairing are mutations affecting CREBBP and KMT2D. Both impair enhancer activity in overlapping pathways to facilitate lymphomagenesis, hence their co-occurrence is especially puzzling. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE224512
ID:
200224512
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

GCB_CK_rep1 [CKDKO_R1]

Organism:
Mus musculus
Source name:
spleen
Platform:
GPL24247
Series:
GSE224512 GSE224513
Download data
Sample
Accession:
GSM7025405
ID:
307025405
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Supplemental Content

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