U.S. flag

An official website of the United States government

Format
Sort by

Send to:

Choose Destination

Search results

Items: 4

1.

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanpolyARNAseq]

(Submitter supplied) RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We find disrupted nuclear RNA surveillance is oncogenic. Cyclin Dependent Kinase 13 (CDK13) is mutated in melanoma and patient-mutated CDK13 accelerates zebrafish melanoma. CDK13 mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
23 Samples
Download data: TXT
Series
Accession:
GSE223891
ID:
200223891
2.

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

(Submitter supplied) RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We find disrupted nuclear RNA surveillance is oncogenic. Cyclin Dependent Kinase 13 (CDK13) is mutated in melanoma and patient-mutated CDK13 accelerates zebrafish melanoma. CDK13 mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. more...
Organism:
Danio rerio; Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
4 related Platforms
87 Samples
Download data: BW, TXT
Series
Accession:
GSE131334
ID:
200131334
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Hg38_A375_CDK13R860Q_rep2

Organism:
Homo sapiens
Source name:
melanoma cell line
Platform:
GPL11154
Series:
GSE131334 GSE223891
Download data: TXT
Sample
Accession:
GSM6998393
ID:
306998393
Format
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GSM6998393[Accession]|query=1|qty=4|blobid=MCID_669ff17056cb0a044e48f8f4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center