GSM6996009[Accession] - GEO DataSets

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Items: 4

Select item 2002238001.

Donor regulatory T cells rapidly adapt to recipient tissues to control acute graft-versus-host disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL16417 GPL21626 GPL24247
548 Samples

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Series

Accession:: GSE223800

ID:: 200223800

Select item 2002237982.

Donor regulatory T cells rapidly adapt to recipient tissues to control acute graft-versus-host disease [scRNA-seq & scTCR-seq]

(Submitter supplied) Adoptive transfer of donor regulatory T cells (Treg) is a promising treatment option for Graft-versus-Host disease (GvHD), but has not yet found its way into routine clinical practice. To map distinctive properties of protective Treg (generated by either polyclonal or allogeneic in vitro expansion), we followed their fate in recipient organs (spleen, liver, colon) in a prophylactic mouse model of MHC-mismatched bone-marrow transplantation (BMT). more...