GSM6924334[Accession] - GEO DataSets

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Items: 4

Select item 2001939291.

Insm1 regulates the expression of thymic tissue-restricted antigens and the immune tolerance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL24247
22 Samples

Download data: BW

Series

Accession:: GSE193929

ID:: 200193929

Select item 2001939262.

Insm1 regulates the expression of thymic tissue-restricted antigens and the immune tolerance [CUT&Tag]

(Submitter supplied) Insm1, encoding a zinc finger protein, is expressed specifically in neuroendocrine cells. Recent study showed the first evidence of Insm1 expression in medullary thymic epithelial cells (mTEC). Here we investigated the expression and function of Insm1 in mTEC. Mutation of Insm1 resulted in decreased proportion of mTEChi although normal development of other types of thymic cells. We detected altered expression of a subset of tissue-restricted antigens (TRAs) and mild decreased expression of Aire and Fezf2 in Insm1 mutant mTEC. more...