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Items: 3

1.

In vivo PIWI slicing in mouse testes deviates from rules established in vitro

(Submitter supplied) Purified endogenous mouse MIWI fails to cleave mismatched targets in vitro. Surprisingly, here we find using knock-in mouse models that piRNA target sites with cleavage-site mismatches are precisely sliced in vivo. This is identical to the slicing outcome in knock-in mice where targets are identified by perfect complementarity base-pairing with the piRNA. Additionally, we find that such pachytene piRNA-guided MIWI/MILI slicing in vivo failed to initiate phased piRNA production from the specific target mRNA we studied. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL19057 GPL24247
26 Samples
Download data: BW, CSV
Series
Accession:
GSE219200
ID:
200219200

PubMed Full text in PMC Similar studies

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10530 Series
300076 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

MD41_1xPerf_MILI IP

Organism:
Mus musculus
Source name:
Testes
Platform:
GPL19057
Series:
GSE219200
Download data: BW
Sample
Accession:
GSM6777743
ID:
306777743

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db=gds|term=GSM6777743[Accession]|query=1|qty=2|blobid=MCID_679343553ebf211704fe4ad9|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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