GSM6760802[Accession] - GEO DataSets

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Items: 4

Select item 2002189581.

Regulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021 GPL21103
111 Samples

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Series

Accession:: GSE218958

ID:: 200218958

PubMed Similar studies

Select item 2002189562.

Regulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [RNA-seq NGS3799]

(Submitter supplied) The cell death protease caspase-8 plays an essential role in controlling inflammation, as severe immunodeficiency results from its loss. We previously found that caspase-8 promotes inflammatory responses by cleaving NEDD4-binding protein 1 (N4BP1), a suppressor of cytokine production, but the underlying mechanisms remained unclear. Here we find that N4BP1 curtails the duration, rather than initial induction, of proinflammatory signaling through a mechanism involving noncanonical IKK (ncIKK)-mediated inhibition of the canonical IkB kinase (IKK) complex, a crosstalk event among the IKK family facilitated by N4BP1. more...