GSM6737571[Accession] - GEO DataSets

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Items: 4

Select item 2002182331.

Molecular Dissection of Polycomb Group Protein-mediated Fetal Hemoglobin Repression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30173
64 Samples

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Series

Accession:: GSE218233

ID:: 200218233

PubMed Full text in PMC Similar studies

Select item 2002182312.

Molecular Dissection of Polycomb Group Protein-mediated Fetal Hemoglobin Repression [CUT&RUN]

(Submitter supplied) The fetal (HbF)-to-adult (HbA) hemoglobin switch is a paradigm for developmental gene expression control with relevance to sickle cell disease and beta-thalassemia. Polycomb repressive complex (PRC) proteins regulate this switch, and an inhibitor of the EED subunit of PRC2 entered clinical trials for fetal hemoglobin activation. Yet, how PcG complexes function in this process, their target genes and relevant subunit composition are unknown. more...