GSM665927[Accession] - GEO DataSets

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Items: 4

Select item 2000270601.

A Bcl6-Smrt/Ncor repression program controls atherosclerosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL6887
10 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE27060

ID:: 200027060

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000270332.

Genome-wide location analysis of SMRT and NCoR in wild-type and Bcl6 knockout macrophages

(Submitter supplied) Using ChIP-seq, we reveal the SMRT and NCoR co-repressor cistromes, which each consist of over 30,000 half-shared binding sites. Moreover, we identify Bcl6-bound sub-cistromes for each co-repressor, which are strongly concentrated on NF-κB-driven inflammatory and tissue remodeling genes. These results reveal a critical role for Bcl6 and its corepressors SMRT and NCoR in the prevention of atherosclerosis and chronic inflammation.