GSM6505953[Accession] - GEO DataSets

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Items: 4

Select item 2002120071.

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL26624 GPL24247 GPL21273
36 Samples

Download data: BW, MTX, TSV

Series

Accession:: GSE212007

ID:: 200212007

PubMed Full text in PMC Similar studies

Select item 2002119412.

CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses [ATAC-seq]

(Submitter supplied) Disruption of Cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we show that CDCA7 is critical for maintaining global DNA methylation levels across multiple tissues in vivo. A pathogenic Cdca7 missense variant leads to the formation of large, aberrantly hypomethylated domains overlapping with the B genomic compartment but without affecting deposition of H3K9 trimethylation (H3K9me3). more...