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Items: 3

1.

Decitabine-induced T cell remodeling facilitates a high antitumor response to PD-1 blockade therapy by promoting the expansion and effector function of CD8+ progenitor exhausted T cells

(Submitter supplied) CD8+ exhausted T (Tex) cells are heterogeneous with distinct transcriptional and epigenetic landscapes. PD-1 inhibitors reinvigorate progenitor Tex cells, which subsequently differentiate into irresponsive terminal Tex cells and impair the longlasting antitumor response of PD-1 blockade therapy. How to maintain durable proliferative capacity of progenitor Tex cells is important but remains largely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL21273 GPL24247
24 Samples
Download data: BEDGRAPH, TAR
Series
Accession:
GSE209965
ID:
200209965
2.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
3.

PD1, replicate2, ATAC-seq

Organism:
Mus musculus
Source name:
colon tumor
Platform:
GPL21273
Series:
GSE209965
Download data
Sample
Accession:
GSM6411765
ID:
306411765
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db=gds|term=GSM6411765[Accession]|query=1|qty=2|blobid=MCID_67aaf564750a117a1d71f678|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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