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Items: 3

1.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

(Submitter supplied) Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient cues adapt insulin secretion by modulating chromatin state and transcription of genes regulating β-cell nutrient sensing and metabolism. Feeding stimulates histone acetylation at sites occupied by the chromatin-modifying enzyme Lsd1 in islets. more...
Organism:
Mus; Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
131 Samples
Download data: BEDGRAPH, DIFF, TXT
Series
Accession:
GSE134901
ID:
200134901
2.

Illumina NovaSeq 6000 (Mus)

Platform
Accession:
GPL31136
ID:
100031136
3.

mm_islets_LsdKIWk3_H3K27ac_ChIPseq_2

Organism:
Mus
Source name:
Pancreatic islets
Platform:
GPL31136
Series:
GSE134901
Download data
Sample
Accession:
GSM6407348
ID:
306407348
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db=gds|term=GSM6407348[Accession]|query=1|qty=4|blobid=MCID_661a96476bc2bd5af4abbe87|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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