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Items: 4

1.

Genomic Collaboration of Estrogen Receptor-α and ERK2 in Regulating Gene and Proliferation Programs

(Submitter supplied) The nuclear hormone receptor, estrogen receptor-alpha (ERα), and MAP kinases both play key roles in hormone-dependent cancers, yet their interplay and the integration of their signaling inputs remain poorly understood. In these studies, we document that estrogen-occupied ERα activates and interacts with ERK2, a downstream effector in the MAPK pathway, resulting in ERK2 and ERα colocalization at chromatin binding sites across the genome of breast cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4052
Platform:
GPL571
30 Samples
Download data: CEL
Series
Accession:
GSE24592
ID:
200024592
2.
Full record GDS4052

Estradiol effect on ERK1/ERK2-deficient MCF-7 breast adenocarcinoma cells: time course

Analysis of MCF7 cells depleted of ERK1 or ERK2 and treated with estradiol for up to 24hrs. ERK1 and ERK2 are downstream effectors in the MAP kinase pathway; estrogen receptor α (ERα) and MAPKs play key roles in hormone-dependent cancers. Results provide insight into ERα and MAPK interactions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 3 genotype/variation, 2 time sets
Platform:
GPL571
Series:
GSE24592
30 Samples
Download data: CEL
3.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...
Organism:
Homo sapiens
84 DataSets
638 Series
12 Related Platforms
24352 Samples
Download data
Platform
Accession:
GPL571
ID:
100000571
4.

siERK2E224h_3496

Organism:
Homo sapiens
Source name:
MCF-7 cells, siERK2 treatment 60h, 10 nM E2 for 24h
Platform:
GPL571
Series:
GSE24592
Dataset:
GDS4052
Download data: CEL
Sample
Accession:
GSM606132
ID:
300606132
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