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Items: 3

1.

Comparative single-cell genomics uncovers evolutionarily conserved features and therapeutic targets in triple-negative breast cancer fibroblasts

(Submitter supplied) We performed scRNA-seq analysis of fibroblasts from murine and human TNBCs. We observed three CAF subtypes in mouse TNBC: two transcriptionally distinct CAFs that were found intermingled and adjacent to tumor cells, and distal CAFs that were located further away from tumor cells. All three CAFs appear to evolve from normal resident fibroblasts/pericytes by activation of Pdgf and Tgfb receptors in fibroblasts in parallel with reciprocal upregulation of ligands in tumor cells and other tumor microenvironment cells. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL24676 GPL21103
13 Samples
Download data: TAR
Series
Accession:
GSE199515
ID:
200199515
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

TNBC1

Organism:
Homo sapiens
Source name:
triple negative breast tumor tissue
Platform:
GPL24676
Series:
GSE199515
Download data: TAR
Sample
Accession:
GSM5974486
ID:
305974486
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db=gds|term=GSM5974486[Accession]|query=1|qty=3|blobid=MCID_67af31ab5b08ab4a17cda380|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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